Lamotrigine and Nuedexta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lamotrigine (lamotrigine) and Nuedexta (dextromethorphan hydrobromide; quinidine sulfate). Common drug interactions include gestational diabetes among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Lamotrigine and Nuedexta. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Nuedexta?

Nuedexta has active ingredients of dextromethorphan hydrobromide; quinidine sulfate. eHealthMe is studying from 3,781 Nuedexta users. Check the latest studies of Nuedexta.

On Jul, 26, 2026

49 people who take Lamotrigine and Nuedexta together, and have interactions are studied.

Lamotrigine and Nuedexta drug interactions.

What are the common drug interactions of Lamotrigine and Nuedexta, by gender? *:

female:

Gestational diabetes (diabetes in pregnancy)
Hand fracture
Headache (pain in head)
Herpes zoster
Hot flush (sudden feelings of heat)
Jc virus test positive
Maternal exposure during pregnancy (use of substance during pregnancy)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)

male:

Fall
Aggression
Erythema (redness of the skin)
Eye pain
Pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Speech disorder
Surgery
Therapeutic response unexpected
Abnormal dreams

What are the common drug interactions of Lamotrigine and Nuedexta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aggression
Confusional state
Drug ineffective
Speech disorder

30-39:

n/a

40-49:

Chronic kidney disease
Therapeutic response unexpected
Abortion spontaneous (naturally occurring miscarriage)
Balance disorder
Bladder disorder
Drug ineffective
Fatigue (feeling of tiredness)
Gestational diabetes (diabetes in pregnancy)
Hospitalisation
Hypoaesthesia (reduced sense of touch or sensation)

50-59:

Drug ineffective
Fall
Burning sensation
Drug effect decreased
Flushing (the warm, red condition of human skin)
Gait disturbance
Impaired driving ability
Joint injury
Joint swelling
Limb injury

60+:

Asthenia (weakness)
Anxiety
Disease progression
Dizziness
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Gait disturbance
Gastrointestinal pain
Hand fracture
Headache (pain in head)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 19 people, 38.78%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 12.24%
Pain: 6 people, 12.24%
Depression: 6 people, 12.24%
Stress And Anxiety: 4 people, 8.16%
Parkinson's Disease: 4 people, 8.16%
Affect Lability (emotional incontinence): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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