Lariam and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lariam (mefloquine hydrochloride) and Aleve (naproxen sodium). Common drug interactions include partner stress among females and affective disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Lariam and Aleve. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Lariam?

Lariam has active ingredients of mefloquine hydrochloride. It is often used in malaria. eHealthMe is studying from 3,145 Lariam users. Check the latest studies of Lariam.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

11 people who take Lariam and Aleve together, and have interactions are studied.

What are the common drug interactions of Lariam and Aleve, by gender? *:

female:

Partner stress
Productive cough
Restlessness (not able to rest)
Self injurious behaviour
Sneezing
Somnolence (a state of near-sleep, a strong desire for sleep)
Sputum discoloured
Tendonitis (a condition that causes pain and swelling of tendons)
Tobacco user
Tooth loss

male:

Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Migraine (headache)
Mobility decreased (ability to move is reduced)
Photosensitivity reaction
Restlessness (not able to rest)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Suicidal ideation
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Lariam and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fear of crowded places
Heart rate irregular
Hypervigilance
Impulsive behaviour
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Nightmare (unpleasant dream)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Personality change
Psychotic disorder

40-49:

n/a

50-59:

n/a

60+:

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Self-injurious ideation
Back pain
Tremor (trembling or shaking movements in one or more parts of your body)
Abasia (inability to walk)
Abdominal discomfort
Abdominal distension
Abnormal dreams
Abnormal sleep-related event
Agitation (state of anxiety or nervous excitement)

What are the existing conditions these people have? *

Depression: 9 people, 81.82%
Quit Smoking: 6 people, 54.55%
Stress And Anxiety: 4 people, 36.36%
Back Pain: 4 people, 36.36%

* Approximation only. Some reports may have incomplete information.

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