Lariam and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lariam (mefloquine hydrochloride) and Spironolactone (spironolactone). Common drug interactions include pancytopenia among females.

The phase IV clinical study analyzes what interactions people have when they take Lariam and Spironolactone. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Lariam?

Lariam has active ingredients of mefloquine hydrochloride. It is often used in malaria. eHealthMe is studying from 3,145 Lariam users. Check the latest studies of Lariam.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

14 people who take Lariam and Spironolactone together, and have interactions are studied.

Lariam and Spironolactone drug interactions.

What are the common drug interactions of Lariam and Spironolactone, by gender? *:

female:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Poikilocytosis (presence of poikilocytes in the blood)
Pulmonary congestion (congestion in the lungs)
Endocarditis (inflammation in heart muscle)
Leukopenia (less number of white blood cells in blood)
Rhonchi (abnormal breath sounds)
Anaemia (lack of blood)
Anisocytosis (patient's red blood cells are of unequal size)

male:

n/a

What are the common drug interactions of Lariam and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Poikilocytosis (presence of poikilocytes in the blood)
Pulmonary congestion (congestion in the lungs)
Endocarditis (inflammation in heart muscle)
Leukopenia (less number of white blood cells in blood)
Rhonchi (abnormal breath sounds)
Anaemia (lack of blood)
Anisocytosis (patient's red blood cells are of unequal size)

What are the existing conditions these people have? *

Leukoencephalopathy (disease of the white matter in the brain): 14 people, 100.00%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 14 people, 100.00%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 12 people, 85.71%
Chronic Renal Failure (kidney failure): 12 people, 85.71%
Hashimoto's Encephalopathy (chronic lymphocytic thyroiditis): 10 people, 71.43%
Diabetes: 7 people, 50.00%
High Blood Pressure: 5 people, 35.71%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 35.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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