Latuda and Keppra drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Latuda (lurasidone hydrochloride) and Keppra (levetiracetam). Common drug interactions include abasia among females and psychiatric decompensation among males.
The phase IV clinical study analyzes what interactions people have when they take Latuda and Keppra. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.
What is Latuda?
Latuda has active ingredients of lurasidone hydrochloride. It is often used in bipolar disorder. eHealthMe is studying from 21,543 Latuda users. Check the latest studies of Latuda.
What is Keppra?
Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.
96 people who take Latuda and Keppra together, and have interactions are studied.

What are the common drug interactions of Latuda and Keppra, by gender? *:
female:
- Abasia (inability to walk)
- Abdominal pain upper
- Aggression
- Alcoholism (problems with alcohol)
- Alopecia (absence of hair from areas of the body)
- Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
- Ankle fracture
- Arthralgia (joint pain)
- Ataxia (loss of full control of bodily movements)
- Aura
male:
- Psychiatric decompensation (worsening of symptoms to the state of a serious mental disorder)
- Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
- Blood glucose increased
- Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
- Ketoacidosis (high concentrations of ketone bodies in blood)
- Leukocytosis (increased white blood cells)
- Local swelling (swelling at the site of some application of substance or injury)
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Pneumonia
- Postictal state
What are the common drug interactions of Latuda and Keppra, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Blood glucose decreased
- Contusion (a type of hematoma of tissue in which capillaries)
- Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
- Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
- Abdominal pain
- Adverse event
- Anoxia (low oxygen)
- Cardiac arrest
- Cardiac disorder
- Drug ineffective
30-39:
- Feeding disorder (when children refuse to eat certain food groups)
- Gait disturbance
- Hallucination (an experience involving the perception of something not present)
- Hypersensitivity
- Intentional self-injury
- Lymphadenopathy (disease or enlargement of lymph nodes)
- Malaise (a feeling of general discomfort or uneasiness)
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Oropharyngeal pain
- Osteoporosis (bones weak and more likely to break)
40-49:
- Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Aggression
- Anaemia (lack of blood)
- Compulsive shopping
- Glomerular filtration rate decreased
- Hypotension (abnormally low blood pressure)
- Mass
- Oculogyric crisis (a spasmodic movement of the eyeballs into a fixed position due to medicine reaction)
- Pain
- Sexually inappropriate behaviour
50-59:
- Fall
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Nausea (feeling of having an urge to vomit)
- Mobility decreased (ability to move is reduced)
- Suicidal ideation
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Pneumonia
- Alcoholism (problems with alcohol)
- Blood potassium decreased
- Crying
60+:
- Tremor (trembling or shaking movements in one or more parts of your body)
- Abdominal discomfort
- Dyskinesia (abnormality or impairment of voluntary movement)
- Dysphagia (a condition in which swallowing is difficult or painful)
- Heart rate decreased
- Hospitalisation
- Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)
- Intervertebral disc protrusion (spinal disc protrusion)
- Malaise (a feeling of general discomfort or uneasiness)
- Nausea (feeling of having an urge to vomit)
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 28 people, 29.17%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 28 people, 29.17%
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 15 people, 15.62%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 9.38%
- Immunodeficiency Common Variable: 8 people, 8.33%
- Depression: 8 people, 8.33%
- Stress And Anxiety: 6 people, 6.25%
- Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 5.21%
- High Blood Pressure: 5 people, 5.21%
* Approximation only. Some reports may have incomplete information.
Do you take Latuda and Keppra?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Latuda and Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Latuda:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Keppra:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Latuda and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keppra and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Reddy, B., Das, S., & Ali, M. , "A Case of Hypersexuality Probably Associated With Lurasidone", Journal of clinical psychopharmacology, 2018 Jan .
- Sood S, "Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone", Clinical Psychopharmacology and Neuroscience, 2017 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
- Reddy, B., Das, S., & Ali, M. , "A Case of Hypersexuality Probably Associated With Lurasidone", Journal of clinical psychopharmacology, 2018 Jan .
- Sood S, "Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone", Clinical Psychopharmacology and Neuroscience, 2017 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on lurasidone hydrochloride and levetiracetam (the active ingredients of Latuda and Keppra, respectively), and Latuda and Keppra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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