Leflunomide and Tapentadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Leflunomide (leflunomide) and Tapentadol (tapentadol). Common drug interactions include vitamin d deficiency among females.

The phase IV clinical study analyzes what interactions people have when they take Leflunomide and Tapentadol. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

What is Tapentadol?

Tapentadol has active ingredients of tapentadol. It is often used in chronic pain. eHealthMe is studying from 2,551 Tapentadol users. Check the latest studies of Tapentadol.

On Jul, 06, 2026

33 people who take Leflunomide and Tapentadol together, and have interactions are studied.

Leflunomide and Tapentadol drug interactions.

What are the common drug interactions of Leflunomide and Tapentadol, by gender? *:

female:

Vitamin d deficiency
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Bacteriuria (presence of bacteria in urine)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Secondary immunodeficiency (lack of immunity due to some disease)
Breast cancer
Immunoglobulins decreased
Fracture
Nerve root compression
Drug ineffective

male:

n/a

What are the common drug interactions of Leflunomide and Tapentadol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Psychotic disorder
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Foot fracture
Intervertebral disc protrusion (spinal disc protrusion)
Mucosal inflammation (infection of mucous membrane)
Osteopenia (a condition where bone mineral density is lower than normal)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Spinal osteoarthritis (joint cartilage loss in spine)
Stomatitis (inflammation of mucous membrane of mouth)
Vitamin d deficiency

60+:

Chest pain
Immunodeficiency
Chills (felling of cold)
Diarrhoea
Lacrimation increased
Peripheral swelling
Pleural effusion (water on the lungs)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Pulmonary embolism (blockage of the main artery of the lung)
Swelling face

What are the existing conditions these people have? *

Pain: 7 people, 21.21%
Menopause (end of monthly cycles in women): 7 people, 21.21%
Impaired Gastric Emptying: 7 people, 21.21%
Adverse Drug Reaction: 3 people, 9.09%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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