Ziac and Ecchymosis - a phase IV clinical study of FDA data

Summary:

Ecchymosis is reported as a side effect among people who take Ziac (bisoprolol fumarate; hydrochlorothiazide), especially for people who are female, 50-59 old, also take Maxalt, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Ecchymosis when taking Ziac. It is created by eHealthMe based on reports of 4,207 people who have side effects when taking Ziac from the FDA, and is updated regularly.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

What is Ecchymosis?

Ecchymosis (a discoloration of the skin resulting from bleeding underneath) is found to be associated with 1,033 drugs and 1,078 conditions by eHealthMe. Check the latest studies of Ecchymosis.

On Jul, 06, 2026

4,207 people reported to have side effects when taking Ziac.
Among them, 12 people (0.29%) have Ecchymosis.

Among these 12 people:

What is the gender of people who have Ecchymosis when taking Ziac? *

female: 91.67 %
male: 8.33 %

What is the age of people who have Ecchymosis when taking Ziac? *

What are other drugs people take besides Ziac? *

What are other side effects people have besides Ecchymosis? *

Fever: 6 people, 50.00%
Joint Pain: 5 people, 41.67%
Fatigue (feeling of tiredness): 5 people, 41.67%
Muscle Aches (muscle pain): 5 people, 41.67%
Hypersensitivity: 5 people, 41.67%
Chest Pain: 5 people, 41.67%
Low Density Lipoprotein Increased (cholesterol increased in blood): 4 people, 33.33%
High Blood Cholesterol: 4 people, 33.33%
Muscle Strain (an injury to a muscle in which the muscle fibres tear): 4 people, 33.33%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 4 people, 33.33%

What are the existing conditions these people have? *

High Blood Cholesterol: 4 people, 33.33%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 25.00%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 8.33%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 1 person, 8.33%
Osteoporosis (bones weak and more likely to break): 1 person, 8.33%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 8.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ziac and have Ecchymosis?

- Check whether Ecchymosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ziac:

Ziac (4,451 reports)

Ecchymosis treatments and more:

Ecchymosis (13,357 reports)

How severe was Ecchymosis and when was it recovered:

Ecchymosis in Ziac

Expand to all the drugs that have ingredients of bisoprolol fumarate; hydrochlorothiazide:

Ecchymosis and drugs with ingredients of bisoprolol fumarate; hydrochlorothiazide (17 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ziac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ecchymosis:

Ecchymosis (1,033 drugs)

Browse all the conditions that are associated with Ecchymosis:

Ecchymosis (1,078 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bisoprolol fumarate; hydrochlorothiazide (the active ingredients of Ziac) and Ziac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.