Leukine and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Leukine (sargramostim) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include alopecia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Leukine and Vicodin. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Leukine?

Leukine has active ingredients of sargramostim. eHealthMe is studying from 2,188 Leukine users. Check the latest studies of Leukine.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

50 people who take Leukine and Vicodin together, and have interactions are studied.

What are the common drug interactions of Leukine and Vicodin, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Conjunctivitis (pink eye)
Erythema of eyelid (redness of the eyelid)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Neck pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rash
Exostosis (formation of new bone on the surface of a bone)
Hepatic lesion

male:

Pyrexia (fever)
Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)
Infection
Injury
Loose tooth
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastases to reproductive organ (cancer spreads to reproductive organ)
Mucosal ulceration (ulcers of mucous membrane)

What are the common drug interactions of Leukine and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Breast cancer female
Intervertebral disc protrusion (spinal disc protrusion)
Osteopenia (a condition where bone mineral density is lower than normal)
Ovarian cyst (fluid filled sac of the ovary)
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Conjunctivitis (pink eye)
Erythema of eyelid (redness of the eyelid)
Eyelid oedema (eyelids are swollen and contain excessive fluid)

40-49:

Headache (pain in head)
Alanine aminotransferase increased
Blood sodium decreased
Cerebral haemorrhage (bleeding within the brain)
Decreased appetite
Epistaxis (bleed from the nose)
Eye pain
Haemoglobin decreased
Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)
Hypersplenism (enlarged spleen and a decrease in one or more types of blood cells)

50-59:

Faeces discoloured
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hepatorenal failure (decrease in kidney function in a person with a severe liver disorder)
Leukocytosis (increased white blood cells)
Lymphocyte count decreased
Lymphocyte count increased
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Monocyte count increased
Nasopharyngitis (inflammation of the nasopharynx)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)

60+:

Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Hot flush (sudden feelings of heat)
Infection
Injury
Loose tooth
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastases to reproductive organ (cancer spreads to reproductive organ)
Mucosal ulceration (ulcers of mucous membrane)

What are the existing conditions these people have? *

Prostate Cancer: 14 people, 28.00%
Vitiligo (pigment is lost from areas of the skin): 12 people, 24.00%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 10.00%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 4 people, 8.00%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 6.00%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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