Levaquin and Donepezil hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Donepezil hydrochloride (donepezil hydrochloride). Common drug interactions include cerebral small vessel ischaemic disease among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Donepezil hydrochloride. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Donepezil hydrochloride?

Donepezil hydrochloride has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 4,263 Donepezil hydrochloride users. Check the latest studies of Donepezil hydrochloride.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

14 people who take Levaquin and Donepezil hydrochloride together, and have interactions are studied.

Levaquin and Donepezil hydrochloride drug interactions.

What are the common drug interactions of Levaquin and Donepezil Hydrochloride, by gender? *:

female:

Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Acute myocardial infarction (acute heart attack)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hypertension (high blood pressure)
Type 2 diabetes mellitus

male:

Cellulitis (infection under the skin)
Hallucination (an experience involving the perception of something not present)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Aggression
Agitation (state of anxiety or nervous excitement)
Blood creatinine increased
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

What are the common drug interactions of Levaquin and Donepezil Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cerebral small vessel ischaemic disease (inadequate blood supply to small blood vessel of brain)
Cerebral ventricle dilatation (enlargement of ventricle of brain)
Acute myocardial infarction (acute heart attack)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hypertension (high blood pressure)
Type 2 diabetes mellitus

60+:

Cellulitis (infection under the skin)
Hallucination (an experience involving the perception of something not present)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Aggression
Agitation (state of anxiety or nervous excitement)
Blood creatinine increased
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 28.57%
Thrombosis (formation of a blood clot inside a blood vessel): 3 people, 21.43%
High Density Lipoprotein Decreased: 3 people, 21.43%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 21.43%
Diabetes: 3 people, 21.43%
Dyspnea (difficult or laboured breathing): 3 people, 21.43%
Abdominal Discomfort: 3 people, 21.43%
Oropharyngeal Pain: 3 people, 21.43%
Multiple Myeloma (cancer of the plasma cells): 2 people, 14.29%
High Blood Cholesterol: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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