Levaquin and Isentress drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Isentress (raltegravir potassium). Common drug interactions include gait disturbance among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Isentress. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Isentress?

Isentress has active ingredients of raltegravir potassium. It is often used in hiv infection. eHealthMe is studying from 16,529 Isentress users. Check the latest studies of Isentress.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

91 people who take Levaquin and Isentress together, and have interactions are studied.

Levaquin and Isentress drug interactions.

What are the common drug interactions of Levaquin and Isentress, by gender? *:

female:

Gait disturbance
Bone density decreased
Osteopenia (a condition where bone mineral density is lower than normal)
Asthenia (weakness)
Arthralgia (joint pain)
Bone loss
Decreased activity
Fear
General physical health deterioration (weak health status)
Hip arthroplasty

male:

Emotional distress
Pain
Osteoporosis (bones weak and more likely to break)
Multiple fractures
Anaemia (lack of blood)
Blood creatinine increased
Renal impairment (severely reduced kidney function)
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Hypokalaemia (low potassium)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the common drug interactions of Levaquin and Isentress, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Quality of life decreased
Decreased activity
Depression
Fear
Fatigue (feeling of tiredness)
Renal failure (kidney dysfunction)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Chronic kidney disease
Bone density decreased
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Depression
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)

50-59:

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intervertebral disc degeneration (spinal disc degeneration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Osteonecrosis (death of bone)
Ankle fracture
Back pain
Balance disorder
Foot fracture

60+:

Renal failure (kidney dysfunction)
Chronic kidney disease
Asthenia (weakness)
Nephropathy (damage to or disease of a kidney)
Osteoporosis (bones weak and more likely to break)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ankle fracture
Arteriovenous fistula site complication
Blood pressure increased
Bone density decreased

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 13.19%
Pain: 10 people, 10.99%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 8.79%
Bacterial Infection: 8 people, 8.79%
Inflammation: 7 people, 7.69%
Stress And Anxiety: 6 people, 6.59%
Nausea (feeling of having an urge to vomit): 6 people, 6.59%
Depression: 6 people, 6.59%
Viral Infection: 5 people, 5.49%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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