Levaquin and Ofirmev drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Ofirmev (acetaminophen). Common drug interactions include tubulointerstitial nephritis among females and cytokine release syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Ofirmev. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Ofirmev?

Ofirmev has active ingredients of acetaminophen. eHealthMe is studying from 817 Ofirmev users. Check the latest studies of Ofirmev.

On Jul, 13, 2026

16 people who take Levaquin and Ofirmev together, and have interactions are studied.

What are the common drug interactions of Levaquin and Ofirmev, by gender? *:

female:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Renal tubular necrosis (death of kidney tubules)
Anaemia (lack of blood)
Diarrhoea
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)

male:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Pyrexia (fever)
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine storm (over-protective immune response that can actually be fatal)
Haematuria (presence of blood in urine)
Hyperkalaemia (damage to or disease of the kidney)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Levaquin and Ofirmev, by age (0-1 to 60+)? *:

0-1:

White blood cell count decreased
Anaemia (lack of blood)
Decreased appetite
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Haemoglobin decreased
Hydrocele
Hypertension (high blood pressure)
Hypoxia (low oxygen in tissues)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pancreatitis (inflammation of pancreas)

2-9:

n/a

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

20-29:

n/a

30-39:

n/a

40-49:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Back pain
Depression
Escherichia bacteraemia (presence of bacteria escherichia coli in the blood)
Neoplasm progression (growth of tumour)
Neuropathy peripheral (surface nerve damage)
Pulmonary embolism (blockage of the main artery of the lung)
Subgaleal haematoma (bleeding in the potential space between the skull periosteum and the scalp galea aponeurosis)
Upper respiratory tract infection

50-59:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Cardiac arrest
Thermal burn (burn by heat)
Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Renal tubular necrosis (death of kidney tubules)
Chronic kidney disease
Fungaemia (fungi circulate in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Rectal haemorrhage (bleeding from anus)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anaemia (lack of blood)
Diarrhoea

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 5 people, 31.25%
Diffuse Large B-Cell Lymphoma Refractory (cancer of b cells, a type of white blood cell-relapsed): 5 people, 31.25%
Febrile Neutropenia (fever with reduced white blood cells): 5 people, 31.25%
High Blood Pressure: 4 people, 25.00%
Pain: 4 people, 25.00%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 4 people, 25.00%
Diarrhea: 3 people, 18.75%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 3 people, 18.75%
Interleukin Level Increased: 3 people, 18.75%
Constipation: 3 people, 18.75%

* Approximation only. Some reports may have incomplete information.

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