Levaquin and Pegasys drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Pegasys (peginterferon alfa 2a). Common drug interactions include blood potassium decreased among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Pegasys. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Pegasys?

Pegasys has active ingredients of peginterferon alfa 2a. It is often used in hepatitis c. eHealthMe is studying from 57,446 Pegasys users. Check the latest studies of Pegasys.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

34 people who take Levaquin and Pegasys together, and have interactions are studied.

What are the common drug interactions of Levaquin and Pegasys, by gender? *:

female:

Blood potassium decreased
Cellulitis (infection under the skin)
Constipation
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Joint stiffness
Upper-airway cough syndrome
Weight decreased
Weight increased

male:

Renal failure (kidney dysfunction)
Liver transplant rejection (failure of liver transplant)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Platelet count decreased
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Drug ineffective
Fatigue (feeling of tiredness)

What are the common drug interactions of Levaquin and Pegasys, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Headache (pain in head)
Influenza like illness
Pain in extremity
Pyrexia (fever)

30-39:

n/a

40-49:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Arrhythmia (irregular heartbeat)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)

50-59:

Renal failure (kidney dysfunction)
Liver transplant rejection (failure of liver transplant)
Multi-organ failure (multisystem organ failure)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Failure to thrive (inadequate weight gain and physical growth in children)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Vomiting

60+:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Injection site inflammation
Lung disorder (lung disease)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 20.59%
Depression: 5 people, 14.71%
Chronic Renal Failure (kidney failure): 4 people, 11.76%
Neuralgia (pain in one or more nerves): 4 people, 11.76%
Infection: 4 people, 11.76%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 11.76%
Fever: 4 people, 11.76%
Pain: 4 people, 11.76%
High Blood Pressure: 3 people, 8.82%
Stress And Anxiety: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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