Levaquin and Phenytoin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Phenytoin (phenytoin). Common drug interactions include vomiting among females and dysphagia among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Phenytoin. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

On Jul, 26, 2026

92 people who take Levaquin and Phenytoin together, and have interactions are studied.

Levaquin and Phenytoin drug interactions.

What are the common drug interactions of Levaquin and Phenytoin, by gender? *:

female:

Vomiting
Asthenia (weakness)
Breast cancer metastatic
Decreased appetite
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Joint injury
Pulmonary embolism (blockage of the main artery of the lung)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Back pain

male:

Dysphagia (a condition in which swallowing is difficult or painful)
Asthenia (weakness)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Deafness unilateral
Dizziness
Eye movement disorder
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)

What are the common drug interactions of Levaquin and Phenytoin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pulmonary embolism (blockage of the main artery of the lung)
Injury
Pain

20-29:

Dry skin
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Hyperkeratosis (thickening of the outer layer of the skin)
Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema (fluid collection in tissue)
Pain
Peripheral ischaemia (impaired circulation to an extremity)
Peroneal nerve palsy
Skin depigmentation (lightening of the skin)

30-39:

Blood creatinine increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Drug ineffective
Hepatic failure (liver failure)

40-49:

Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Oxygen saturation decreased
Placental disorder
Placental infarction (interruption of blood supply to a part of the placenta, causing its cells to die)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pyrexia (fever)
Sputum retention
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

50-59:

Cystitis (inflammation of the wall of the bladder)
Dizziness
Full blood count decreased
Gastric disorder (disease of stomach)
Hypoaesthesia (reduced sense of touch or sensation)
Ingrowing nail
Loss of consciousness
Palpitations (feelings or sensations that your heart is pounding or racing)
Platelet count decreased
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)

60+:

Dysphagia (a condition in which swallowing is difficult or painful)
Nausea (feeling of having an urge to vomit)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Speech disorder
Weight decreased
Abdominal pain
Anaemia (lack of blood)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Arteriosclerosis (thickening and hardening of arteries)
Back pain

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 13.04%
High Blood Cholesterol: 11 people, 11.96%
Pain: 9 people, 9.78%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 9 people, 9.78%
Nuclear Magnetic Resonance Imaging Brain: 8 people, 8.70%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 8 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 8.70%
Joint Pain: 6 people, 6.52%
Ingrowing Nail: 6 people, 6.52%
Depression: 6 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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