Levaquin and Pyridium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Pyridium (phenazopyridine hydrochloride). Common drug interactions include cystitis interstitial among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Pyridium. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

On Jul, 12, 2026

92 people who take Levaquin and Pyridium together, and have interactions are studied.

Levaquin and Pyridium drug interactions.

What are the common drug interactions of Levaquin and Pyridium, by gender? *:

female:

Cystitis interstitial (unknown cause characterized by bladder pain)
Haemoglobin decreased
Pyrexia (fever)
Vomiting
Back pain
Fungal infection
Platelet count decreased
Diarrhoea
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Osteoporosis (bones weak and more likely to break)

male:

Depression
Renal failure (kidney dysfunction)
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic anaemia (anaemia due to kidney disease)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Vomiting
Abdominal pain

What are the common drug interactions of Levaquin and Pyridium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Death

20-29:

Activities of daily living impaired
Arthralgia (joint pain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Comminuted fracture (bone has broken into several pieces)
Cystitis interstitial (unknown cause characterized by bladder pain)
Fall
Femur fracture
Haemoglobin decreased
Mobility decreased (ability to move is reduced)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

30-39:

Nausea (feeling of having an urge to vomit)
Pain
Abasia (inability to walk)
Abdominal pain
Arthralgia (joint pain)
Asthma
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Chest discomfort

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Nephrogenic anaemia (anaemia due to kidney disease)
Anxiety
Depression
Cardiac failure congestive
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Calciphylaxis (is a syndrome with vascular calcium accumulation)

50-59:

Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Back pain
Bacteraemia (presence of bacteria in the blood)
Bladder disorder
Bone disorder
Calcium deficiency (lack of calcium)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest discomfort

60+:

Drug hypersensitivity
Chronic kidney disease
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Weight decreased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Anxiety
Cystitis interstitial (unknown cause characterized by bladder pain)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Pain: 29 people, 31.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 22 people, 23.91%
High Blood Cholesterol: 15 people, 16.30%
Depression: 10 people, 10.87%
Infection: 10 people, 10.87%
High Blood Pressure: 8 people, 8.70%
Nausea (feeling of having an urge to vomit): 8 people, 8.70%
Diabetes: 8 people, 8.70%
Headache (pain in head): 8 people, 8.70%
Stress And Anxiety: 7 people, 7.61%

* Approximation only. Some reports may have incomplete information.

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