Levaquin and Rifaximin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Rifaximin (rifaximin). Common drug interactions include drug hypersensitivity among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Rifaximin. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Rifaximin?

Rifaximin has active ingredients of rifaximin. eHealthMe is studying from 3,597 Rifaximin users. Check the latest studies of Rifaximin.

On Jul, 16, 2026

22 people who take Levaquin and Rifaximin together, and have interactions are studied.

Levaquin and Rifaximin drug interactions.

What are the common drug interactions of Levaquin and Rifaximin, by gender? *:

female:

Drug hypersensitivity
Insomnia (sleeplessness)
Thrombocytopenia (decrease of platelets in blood)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Atelectasis (partial or complete collapse of the lung)
Chronic kidney disease
Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Metastases to liver (cancer spreads to liver)
Nephrogenic anaemia (anaemia due to kidney disease)
Pancreatic carcinoma (pancreatic cancer)
Renal injury (kidney injury)

What are the common drug interactions of Levaquin and Rifaximin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Influenza
Weight decreased

30-39:

n/a

40-49:

Leukocytosis (increased white blood cells)
Metastases to liver (cancer spreads to liver)
Pancreatic carcinoma (pancreatic cancer)
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)

50-59:

Bacteraemia (presence of bacteria in the blood)
Blood pressure increased
Drug hypersensitivity
Insomnia (sleeplessness)
Thrombocytopenia (decrease of platelets in blood)
Chronic kidney disease
Renal failure (kidney dysfunction)
Atelectasis (partial or complete collapse of the lung)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Abdominal pain

60+:

Ascites (accumulation of fluid in the abdominal cavity)
Chest pain
Respiratory distress (difficulty in breathing)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hearing impaired
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Loss of consciousness
Pain
Pneumonia viral

What are the existing conditions these people have? *

Pain: 7 people, 31.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 31.82%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 5 people, 22.73%
Rickets (softening of bones): 5 people, 22.73%
Osteoporosis (bones weak and more likely to break): 5 people, 22.73%
Diarrhea: 5 people, 22.73%
Stress And Anxiety: 4 people, 18.18%
Sleep Disorder: 4 people, 18.18%
Depression: 4 people, 18.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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