Levaquin and Roxanol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Roxanol (morphine sulfate). Common drug interactions include oedema peripheral among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Roxanol. It is created by eHealthMe based on reports of 93 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Roxanol?

Roxanol has active ingredients of morphine sulfate. eHealthMe is studying from 807 Roxanol users. Check the latest studies of Roxanol.

On Aug, 06, 2026

93 people who take Levaquin and Roxanol together, and have interactions are studied.

What are the common drug interactions of Levaquin and Roxanol, by gender? *:

female:

Oedema peripheral (superficial swelling)
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Osteonecrosis of jaw (death of bone of jaw)
Back pain
Cough
Metastases to bone (cancer spreads to bone)
Bone disorder
Pain in extremity
Deformity (disfigurement)

male:

Anxiety
Pain
Diarrhoea
Fatigue (feeling of tiredness)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Back pain
Cardiomegaly (increased size of heart than normal)
Cardiac failure congestive
Metastases to bone (cancer spreads to bone)
Metastases to spine (cancer spreads to spine)

What are the common drug interactions of Levaquin and Roxanol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Malaise (a feeling of general discomfort or uneasiness)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

n/a

30-39:

Anxiety
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Abdominal pain upper
Asthenia (weakness)
Back pain
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

40-49:

Anxiety
Injury
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Diarrhoea
Fatigue (feeling of tiredness)
Metastases to bone (cancer spreads to bone)
Metastases to spine (cancer spreads to spine)
Myalgia (muscle pain)

50-59:

Cough
Rash
Dysuria (painful or difficult urination)
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint stiffness
Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin exfoliation (removal of the oldest dead skin cells)
Skin fibrosis (fibrous tissue formation on skin)

60+:

Anxiety
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone disorder
Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Pain: 33 people, 35.48%
Nausea (feeling of having an urge to vomit): 16 people, 17.20%
Multiple Myeloma (cancer of the plasma cells): 16 people, 17.20%
Nuclear Magnetic Resonance Imaging Brain: 11 people, 11.83%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 11 people, 11.83%
High Blood Cholesterol: 11 people, 11.83%
Depression: 11 people, 11.83%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 11 people, 11.83%
Bone Density Decreased: 11 people, 11.83%
Stress And Anxiety: 10 people, 10.75%

* Approximation only. Some reports may have incomplete information.

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