Levaquin and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levaquin (levofloxacin) and Soliris (eculizumab). Common drug interactions include nausea among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Levaquin and Soliris. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Jul, 10, 2026

96 people who take Levaquin and Soliris together, and have interactions are studied.

What are the common drug interactions of Levaquin and Soliris, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Blood creatinine increased
Blood urea increased
Fatigue (feeling of tiredness)
Glomerular filtration rate decreased
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Blood pressure decreased
Escherichia sepsis (bacterial infection by escherichia coli)
Headache (pain in head)
Neutropenia (an abnormally low number of neutrophils)

male:

Pyrexia (fever)
Back pain
Influenza like illness
Photopsia (presence of perceived flashes of light)
Platelet count increased
Upper respiratory tract infection
Anaemia (lack of blood)
Drug ineffective
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Pancreatitis (inflammation of pancreas)

What are the common drug interactions of Levaquin and Soliris, by age (0-1 to 60+)? *:

0-1:

Death

2-9:

Blood creatinine increased
Bone marrow failure
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Nuclear magnetic resonance imaging brain
Pyrexia (fever)

10-19:

n/a

20-29:

Pyrexia (fever)
Back pain
Drug ineffective
Abdominal pain upper
Blood glucose increased
Duodenogastric reflux (bile flows upward from the small intestine into the stomach)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)

30-39:

Vomiting
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Abdominal pain
Abdominal pain upper
Blood pressure increased
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Gastric ulcer (stomach ulcer)
Gastrointestinal inflammation (inflammation of stomach and intestine)

40-49:

Dyspnoea (difficult or laboured respiration)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hypoperfusion (decreased blood flow through an organ)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Hepatic enzyme increased
Multiple allergies (allergy to multiple agents)
Platelet count decreased
Productive cough

50-59:

Haematocrit decreased
White blood cell count decreased
Disease progression
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Escherichia sepsis (bacterial infection by escherichia coli)
Haemoglobin decreased
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Arteriosclerosis (thickening and hardening of arteries)

60+:

Anaemia (lack of blood)
Blood lactate dehydrogenase increased
Upper respiratory tract infection
Blood creatinine increased
Blood urea increased
Glomerular filtration rate decreased
Haematocrit decreased
Failure to thrive (inadequate weight gain and physical growth in children)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Influenza like illness

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 59 people, 61.46%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 18 people, 18.75%
Pain: 11 people, 11.46%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 10 people, 10.42%
Anaemia (lack of blood): 9 people, 9.38%
Stress And Anxiety: 7 people, 7.29%
Nausea (feeling of having an urge to vomit): 7 people, 7.29%
High Blood Pressure: 6 people, 6.25%
Insomnia (sleeplessness): 5 people, 5.21%
Haemoglobin Decreased: 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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