Levemir and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levemir (insulin detemir recombinant) and Vytorin (ezetimibe; simvastatin). Common drug interactions include glycosylated haemoglobin increased among females and blood glucose decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Levemir and Vytorin. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Levemir?

Levemir has active ingredients of insulin detemir recombinant. It is often used in diabetes. eHealthMe is studying from 13,850 Levemir users. Check the latest studies of Levemir.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

On Jul, 12, 2026

77 people who take Levemir and Vytorin together, and have interactions are studied.

What are the common drug interactions of Levemir and Vytorin, by gender? *:

female:

Glycosylated haemoglobin increased
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Exostosis (formation of new bone on the surface of a bone)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Nerve compression

male:

Blood glucose decreased
Blood glucose increased
Asthenia (weakness)
Blood glucose fluctuation
Cardiomegaly (increased size of heart than normal)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diarrhoea
Dizziness
Drug ineffective
Fall

What are the common drug interactions of Levemir and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Gallbladder disorder
Injury

30-39:

n/a

40-49:

Anxiety
Chest pain
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Glycosylated haemoglobin increased
Injection site mass
Pancreatitis acute (sudden inflammation of pancreas)
Pulmonary embolism (blockage of the main artery of the lung)
Renal failure acute (rapid kidney dysfunction)

50-59:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abdominal discomfort
Abdominal pain
Abnormal dreams
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Bile duct stone
Blood magnesium decreased
Blood pressure decreased

60+:

Blood glucose increased
Dizziness
Fluid retention (an abnormal accumulation of fluid in the blood)
Glycosylated haemoglobin increased
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Blood glucose decreased
Dyspnoea (difficult or laboured respiration)
Fall
Febrile neutropenia (fever with reduced white blood cells)
Gastroenteritis (inflammation of stomach and intestine)

What are the existing conditions these people have? *

High Blood Pressure: 8 people, 10.39%
Type 2 Diabetes: 6 people, 7.79%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 7.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.49%
Birth Control: 5 people, 6.49%
Type 1 Diabetes: 4 people, 5.19%
Premenstrual Syndrome: 4 people, 5.19%
Neuropathy Peripheral (surface nerve damage): 4 people, 5.19%
Migraine (headache): 4 people, 5.19%
Intervertebral Disc Protrusion (spinal disc protrusion): 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

Do you take Levemir and Vytorin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously