Levofloxacin and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levofloxacin (levofloxacin; sodium chloride) and Codeine (codeine sulfate). Common drug interactions include frustration among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Levofloxacin and Codeine. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Levofloxacin?

Levofloxacin has active ingredients of levofloxacin; sodium chloride. It is often used in sinusitis. eHealthMe is studying from 16,335 Levofloxacin users. Check the latest studies of Levofloxacin.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Aug, 12, 2026

42 people who take Levofloxacin and Codeine together, and have interactions are studied.

Levofloxacin and Codeine drug interactions.

What are the common drug interactions of Levofloxacin and Codeine, by gender? *:

female:

Frustration (a form of poorly expressed anger)
Gastric mucosal hypertrophy (inflammation and ulcers (breaks on the skin or on the surface of an organ) of the mucosa (inner lining) of the stomach)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematemesis (vomiting of blood)
Haematuria (presence of blood in urine)
Herpes zoster
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

male:

Dyspnoea (difficult or laboured respiration)
Febrile neutropenia (fever with reduced white blood cells)
Osteomyelitis (infection of bone)
Peripheral ischaemia (impaired circulation to an extremity)
Death
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Renal failure acute (rapid kidney dysfunction)
Cardiac failure congestive
Respiratory failure (inadequate gas exchange by the respiratory system)
Gait disturbance

What are the common drug interactions of Levofloxacin and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Frustration (a form of poorly expressed anger)
Gastric mucosal hypertrophy (inflammation and ulcers (breaks on the skin or on the surface of an organ) of the mucosa (inner lining) of the stomach)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematemesis (vomiting of blood)
Haematuria (presence of blood in urine)
Headache (pain in head)

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Arthralgia (joint pain)
Bone pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Gastritis (inflammation of stomach)
Muscle tightness
Myalgia (muscle pain)
Tendonitis (a condition that causes pain and swelling of tendons)

60+:

Febrile neutropenia (fever with reduced white blood cells)
Neutropenia (an abnormally low number of neutrophils)
Lower respiratory tract infection
Osteomyelitis (infection of bone)
Peripheral ischaemia (impaired circulation to an extremity)
Death
C-reactive protein increased
Cough
Delirium (wild excitement)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)

What are the existing conditions these people have? *

Pneumonia: 10 people, 23.81%
Arthropathy: 9 people, 21.43%
High Blood Pressure: 8 people, 19.05%
Cough: 8 people, 19.05%
Polymyalgia Rheumatica (pain in many muscles): 6 people, 14.29%
Nausea (feeling of having an urge to vomit): 4 people, 9.52%
Lower Respiratory Tract Infection: 4 people, 9.52%
Gout (uric acid crystals building up in the body): 4 people, 9.52%
Type 2 Diabetes: 3 people, 7.14%
Non-Hodgkin's Lymphoma Unspecified Histology Indolent (malignant (cancer) cells form in the lymph system- unspecified histology indolent): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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