Levofloxacin and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levofloxacin (levofloxacin; sodium chloride) and Ultram (tramadol hydrochloride). Common drug interactions include conjunctivitis among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Levofloxacin and Ultram. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Levofloxacin?

Levofloxacin has active ingredients of levofloxacin; sodium chloride. It is often used in sinusitis. eHealthMe is studying from 16,335 Levofloxacin users. Check the latest studies of Levofloxacin.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 17, 2026

27 people who take Levofloxacin and Ultram together, and have interactions are studied.

Levofloxacin and Ultram drug interactions.

What are the common drug interactions of Levofloxacin and Ultram, by gender? *:

female:

Conjunctivitis (pink eye)
Constipation
Coronary artery thrombosis (clot formation in coronary artery)
Cough
Cryptococcosis (potentially fatal fungal disease)
Cystitis glandularis (forming a timorous lesion with blueberry spots in the urinary bladder)
Deafness
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)

male:

Agitation (state of anxiety or nervous excitement)
Confusional state
Pseudomonal bacteraemia (p. aeruginosa cause of bacterial infections of the blood)
Urinary hesitation (difficulty in beginning the flow of urine)
Bacterial infection
Blood culture positive
Hypotension (abnormally low blood pressure)
Urinary retention (the inability to completely or partially empty the bladder)
Culture positive
Diarrhoea

What are the common drug interactions of Levofloxacin and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Injury
Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Injury
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)

30-39:

Blood culture positive
Cryptococcosis (potentially fatal fungal disease)
Full blood count decreased
Myalgia (muscle pain)

40-49:

Drug hypersensitivity
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Ear pain
Early satiety (feeling full before completing a normal sized meal)
Emotional disorder
Erythema (redness of the skin)
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

50-59:

Arthralgia (joint pain)
Bone pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac disorder
Death
Hypotension (abnormally low blood pressure)
Muscle tightness
Myalgia (muscle pain)
Renal impairment (severely reduced kidney function)
Tendonitis (a condition that causes pain and swelling of tendons)

60+:

Agitation (state of anxiety or nervous excitement)
Confusional state
Death
Enterococcal infection
Nausea (feeling of having an urge to vomit)
Pseudomonal bacteraemia (p. aeruginosa cause of bacterial infections of the blood)
Urinary hesitation (difficulty in beginning the flow of urine)
Anxiety
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacterial infection

What are the existing conditions these people have? *

Stable Angina (a constant chest pain): 5 people, 18.52%
Femoral Neck Fracture (neck of femur bone fracture): 5 people, 18.52%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 18.52%
Nausea (feeling of having an urge to vomit): 2 people, 7.41%
Colon Cancer: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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