Levonorgestrel and Clonidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levonorgestrel (levonorgestrel) and Clonidine (clonidine). Common drug interactions include hypertensive emergency among females.

The phase IV clinical study analyzes what interactions people have when they take Levonorgestrel and Clonidine. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Levonorgestrel?

Levonorgestrel has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 4,186 Levonorgestrel users. Check the latest studies of Levonorgestrel.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 22, 2026

20 people who take Levonorgestrel and Clonidine together, and have interactions are studied.

Levonorgestrel and Clonidine drug interactions.

What are the common drug interactions of Levonorgestrel and Clonidine, by gender? *:

female:

  1. Hypertensive emergency
  2. Haemorrhage intracranial (bleeding within the skull)
  3. Influenza
  4. Aggression
  5. Anger
  6. Anxiety
  7. Bipolar disorder (mood disorder)
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Cholinergic syndrome (symptoms of increased cholinergic stimulation)
  10. Cough

male:

n/a

What are the common drug interactions of Levonorgestrel and Clonidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Aggression
  2. Anger
  3. Bipolar disorder (mood disorder)
  4. Depression
  5. Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
  6. Hyperphagia (an abnormal appetite for food)
  7. Intentional self-injury
  8. Memory impairment
  9. Panic attack
  10. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

10-19:

n/a

20-29:

  1. Neutropenia (an abnormally low number of neutrophils)

30-39:

  1. Basal ganglia haemorrhage (bleeding from blood vessels in an area of the brain responsible for body movements)
  2. Hemiparesis (weakness on one side of the body)
  3. Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
  4. Sympathomimetic effect (substances that mimic the effects of the hormone epinephrine (adrenaline)
  5. Adrenergic syndrome
  6. Facial paralysis (loss of function of face muscle)
  7. Anxiety
  8. Cholinergic syndrome (symptoms of increased cholinergic stimulation)
  9. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  10. Fall

40-49:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Cough
  3. Dizziness
  4. Dyspnoea (difficult or laboured respiration)
  5. Fatigue (feeling of tiredness)
  6. Influenza
  7. Swelling

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Stress And Anxiety: 9 people, 45.00%
  2. Erection Problems: 3 people, 15.00%
  3. Disturbance In Sexual Arousal: 3 people, 15.00%
  4. Immunodeficiency Common Variable: 2 people, 10.00%
  5. Sexual Inhibition (a low level of sexual interest): 1 person, 5.00%
  6. Sexual Activity Increased: 1 person, 5.00%
  7. Nausea And Vomiting: 1 person, 5.00%
  8. Headache (pain in head): 1 person, 5.00%
  9. Depression: 1 person, 5.00%
  10. Asthma: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Levonorgestrel and Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Levonorgestrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Levonorgestrel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clonidine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel and clonidine (the active ingredients of Levonorgestrel and Clonidine, respectively), and Levonorgestrel and Clonidine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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