Levonorgestrel and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levonorgestrel (levonorgestrel) and Methotrexate (methotrexate sodium). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Levonorgestrel and Methotrexate. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Levonorgestrel?

Levonorgestrel has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 4,186 Levonorgestrel users. Check the latest studies of Levonorgestrel.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 10, 2026

81 people who take Levonorgestrel and Methotrexate together, and have interactions are studied.

Levonorgestrel and Methotrexate drug interactions.

What are the common drug interactions of Levonorgestrel and Methotrexate, by gender? *:

female:

Drug ineffective
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Limb discomfort (discomfort in leg)
Pain
Pneumonia
Myalgia (muscle pain)
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Asthenia (weakness)
Fibromyalgia (a long-term condition which causes pain all over the body)

male:

n/a

What are the common drug interactions of Levonorgestrel and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Post procedural haemorrhage (post procedural bleeding)
Barotrauma (injury to body because of changes in barometric (air) or water pressure)
Diarrhoea
Gamma-glutamyltransferase increased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nausea (feeling of having an urge to vomit)
Sacroiliitis (an inflammation of the sacroiliac joint)
Vertigo
Vitamin d decreased

20-29:

Hemiparesis (weakness on one side of the body)
Pain
Acute lymphocytic leukaemia (cancer of the white blood cells)
Chest pain
Costochondritis (chest wall pain)
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

30-39:

Lymphadenopathy (disease or enlargement of lymph nodes)
Maternal exposure during pregnancy (use of substance during pregnancy)
Nasopharyngitis (inflammation of the nasopharynx)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Productive cough
Pyrexia (fever)
Rash pruritic (redness with itching)
Respiratory tract infection
Rhinorrhoea (watery mucus discharge from the nose)
Sinusitis (inflammation of sinus)

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Anaemia (lack of blood)
Anal abscess
Anal fistula
Breast cyst
Chest discomfort
Chest pain
Cough
Deafness
Drug ineffective

50-59:

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Night sweats (sweating in night)
Pain in extremity
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Thyroiditis (inflammation of thyroid gland)
Tinnitus (a ringing in the ears)
Uterine enlargement
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Vertigo
Tenderness (pain or discomfort when an affected area is touched)

60+:

Abortion spontaneous (naturally occurring miscarriage)
Lung adenocarcinoma (a form of non-small cell lung cancer)
Pregnancy on contraceptive
Urinary tract infection
Venous thrombosis limb (blood clot that forms in a vein in the limb)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 10 people, 12.35%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 10 people, 12.35%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 11.11%
Pain: 8 people, 9.88%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 7.41%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 7.41%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 6.17%
Nasal Septum Deviation (deviated nasal septum): 5 people, 6.17%
High Blood Pressure: 5 people, 6.17%
Depression: 5 people, 6.17%

* Approximation only. Some reports may have incomplete information.

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