Levothyroxine sodium and Avalide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothyroxine sodium (levothyroxine sodium) and Avalide (hydrochlorothiazide; irbesartan). Common drug interactions include terminal state among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Levothyroxine sodium and Avalide. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,813 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Avalide?

Avalide has active ingredients of hydrochlorothiazide; irbesartan. It is often used in high blood pressure. eHealthMe is studying from 5,943 Avalide users. Check the latest studies of Avalide.

On Aug, 11, 2026

98 people who take Levothyroxine sodium and Avalide together, and have interactions are studied.

Levothyroxine sodium and Avalide drug interactions.

What are the common drug interactions of Levothyroxine Sodium and Avalide, by gender? *:

female:

Terminal state (the transitional states between life and biological death)
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Pyrexia (fever)
Blood cortisol decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Diarrhoea
Nausea (feeling of having an urge to vomit)
Respiratory rate decreased (less breathing rate/min)

male:

Depression
Drug ineffective
Cerebral haemorrhage (bleeding within the brain)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Death
Dizziness
Emotional distress
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Hypoxia (low oxygen in tissues)

What are the common drug interactions of Levothyroxine Sodium and Avalide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pain
Anxiety
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Emotional distress
General physical health deterioration (weak health status)
Injury
Joint swelling
Lower extremity mass (mass in lower legs)

50-59:

Cardiac murmur (an heart sound in valve abnormality)
Cardiomegaly (increased size of heart than normal)
Decreased appetite
Erythema (redness of the skin)
Haemorrhage (bleeding)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatic steatosis (fatty liver disease)
Injection site pain

60+:

Depression
Fatigue (feeling of tiredness)
Weight decreased
Dehydration (dryness resulting from the removal of water)
Anxiety
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased
Decreased appetite
Diarrhoea

What are the existing conditions these people have? *

High Blood Cholesterol: 12 people, 12.24%
Diabetes: 12 people, 12.24%
Thyroid Diseases: 8 people, 8.16%
Osteoporosis (bones weak and more likely to break): 6 people, 6.12%
Depression: 5 people, 5.10%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 5.10%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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