Levothyroxine sodium and Sonata drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levothyroxine sodium (levothyroxine sodium) and Sonata (zaleplon). Common drug interactions include anxiety among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Levothyroxine sodium and Sonata. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,812 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.

What is Sonata?

Sonata has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 3,330 Sonata users. Check the latest studies of Sonata.

On Jul, 09, 2026

69 people who take Levothyroxine sodium and Sonata together, and have interactions are studied.

Levothyroxine sodium and Sonata drug interactions.

What are the common drug interactions of Levothyroxine Sodium and Sonata, by gender? *:

female:

Anxiety
Chest discomfort
Multiple injuries
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Pain in extremity
Type 2 diabetes mellitus
Abnormal behaviour
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

male:

Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Cardiac disorder
Cardiac failure
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Dizziness

What are the common drug interactions of Levothyroxine Sodium and Sonata, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Obesity (having too much body fat)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

30-39:

Anxiety
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Cholecystitis chronic (long lasting infection of gallbladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Emotional distress
Gallbladder disorder
General physical health deterioration (weak health status)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hyperglycaemia (high blood sugar)
Injury

40-49:

Aphthous stomatitis (mouth ulcer)
Colitis ulcerative (inflammation of colon with ulcer)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Depression
Inflammatory bowel disease
Oral herpes (viral infection of mouth)
Proctitis (inflammation of the rectum and anus)
Small intestinal obstruction (blockage in small intestine)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Fibromyalgia (a long-term condition which causes pain all over the body)

50-59:

Small intestinal obstruction (blockage in small intestine)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Chest discomfort
Chest pain
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Gallbladder disorder
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hallucination, visual (seeing things that aren't there)

60+:

Diarrhoea
Drug ineffective
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)
Haemorrhage (bleeding)
Heart rate decreased
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Injection site infection

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 21.74%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 18.84%
Rosacea (a skin condition that causes facial redness): 9 people, 13.04%
Acne (skin problems that cause pimples): 9 people, 13.04%
Depression: 8 people, 11.59%
Sleep Disorder: 6 people, 8.70%
Thyroid Diseases: 5 people, 7.25%
Neuralgia (pain in one or more nerves): 5 people, 7.25%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 7.25%
High Blood Cholesterol: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

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