Levoxyl and Cogentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Cogentin (benztropine mesylate). Common drug interactions include accident among females and type 2 diabetes mellitus among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Cogentin. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Cogentin?

Cogentin has active ingredients of benztropine mesylate. It is often used in tardive dyskinesia. eHealthMe is studying from 7,692 Cogentin users. Check the latest studies of Cogentin.

On Jul, 25, 2026

49 people who take Levoxyl and Cogentin together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Cogentin, by gender? *:

female:

Accident
Cataract (clouding of the lens inside the eye)
Contusion (a type of hematoma of tissue in which capillaries)
Fibromyalgia (a long-term condition which causes pain all over the body)
Restless legs syndrome (a powerful urge to move your legs)
Swollen tongue (swelling of tongue)
Abscess jaw (tooth abscess or root abscess)
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)

male:

Type 2 diabetes mellitus
Diabetes mellitus inadequate control
Hyperlipidaemia (presence of excess lipids in the blood)
Obesity (having too much body fat)
Renal failure (kidney dysfunction)
Bipolar disorder (mood disorder)
Blood triglycerides increased
Confusion
Constipation
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

What are the common drug interactions of Levoxyl and Cogentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Disease complication
Megacolon (a very dilated colon)
Abnormal behaviour
Diabetes mellitus inadequate control
Hyperprolactinaemia (abnormally high levels of prolactin in the blood)
Immune system disorder
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Type 2 diabetes mellitus

20-29:

Anaemia (lack of blood)
Confusional state
Hepatitis (inflammation of the liver)
Infection
Mania (a state of abnormally elevated or irritable mood)
Memory impairment
Pneumonia
Pyrexia (fever)
Rigors (an episode of shaking or exaggerated shivering)
Sinusitis (inflammation of sinus)

30-39:

Diabetes mellitus inadequate control
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Gout (uric acid crystals building up in the body)
Hyperglycaemia (high blood sugar)
Type 2 diabetes mellitus
Abdominal pain upper
Arthralgia (joint pain)
Blood cholesterol increased
Blood triglycerides increased

40-49:

Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Post procedural infection
Prostatitis (inflammation of the prostate gland)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Psychotic disorder
Radiculitis (inflammation of the spinal nerve roots)
Respiratory tract congestion (blockage on respiratory system)
Suicidal ideation
Trismus (reduced opening of the jaws)

50-59:

Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Diabetic coma
Diabetic nephropathy (diabetic kidney disease)
Malaise (a feeling of general discomfort or uneasiness)
Nephrogenic diabetes insipidus (a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine)
Somnolence (a state of near-sleep, a strong desire for sleep)
Aggression
Angioedema (rapid swelling of the dermis)
Bipolar disorder (mood disorder)
Blood cholesterol increased

60+:

Contusion (a type of hematoma of tissue in which capillaries)
Dyspnoea (difficult or laboured respiration)
Pruritus (severe itching of the skin)
Sedation
Injection site cellulitis (injection site inflammation)
Injection site haemorrhage (bleeding from injection site)
Injection site reaction
Restless legs syndrome (a powerful urge to move your legs)
Coma (state of unconsciousness lasting more than six hours)
Confusion

What are the existing conditions these people have? *

Depression: 14 people, 28.57%
Bipolar Disorder (mood disorder): 8 people, 16.33%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 6 people, 12.24%
Weight Loss: 4 people, 8.16%
Stress And Anxiety: 4 people, 8.16%
High Blood Pressure: 4 people, 8.16%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 6.12%
Pain: 3 people, 6.12%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 6.12%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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