Levoxyl and Esgic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Esgic (acetaminophen; butalbital; caffeine). Common drug interactions include syncope among females.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Esgic. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

On Jul, 26, 2026

11 people who take Levoxyl and Esgic together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Esgic, by gender? *:

female:

Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal pain
Hepatic mass
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Neck pain

male:

n/a

What are the common drug interactions of Levoxyl and Esgic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Insomnia (sleeplessness)

40-49:

Anxiety
Chest discomfort
Dry eye (lack of adequate tears)
Epicondylitis (tennis elbow)
Exostosis (formation of new bone on the surface of a bone)
Eye allergy
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Laceration (tearing of soft body tissue)
Ligament rupture (tear in ligament)

50-59:

n/a

60+:

Pancreatitis (inflammation of pancreas)
Cough
Flushing (the warm, red condition of human skin)
Muscle cramp (painful sensation caused by muscle contraction)
Muscle spasms (muscle contraction)
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Oesophageal spasm (contraction of oesophagus)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dizziness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 27.27%
Type 2 Diabetes: 2 people, 18.18%
Osteoporosis (bones weak and more likely to break): 2 people, 18.18%
Drowsiness: 2 people, 18.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Headache (pain in head): 1 person, 9.09%
Dementia (madness): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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