Levoxyl and Nicotine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Nicotine (nicotine). Common drug interactions include suicidal ideation among females and angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Nicotine. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

On Jul, 06, 2026

28 people who take Levoxyl and Nicotine together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Nicotine, by gender? *:

female:

Suicidal ideation
Lower limb fracture
Radiculitis lumbosacral (inflammation of nerve root at labosacral vertebrea)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Spinal osteoarthritis (joint cartilage loss in spine)
Upper limb fracture
Vaginitis bacterial (inflammation of the vagina caused by bacterial infection)
Accident
Affective disorder (mental disorder)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)

male:

Angioedema (rapid swelling of the dermis)
Anorectal discomfort
Drug dependence
Drug tolerance increased
Fall
Gait disturbance
Gout (uric acid crystals building up in the body)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Levoxyl and Nicotine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Back pain
Bone erosion
Bone swelling
Cellulitis (infection under the skin)
Chills (felling of cold)
Dental caries
Disability
Hypoaesthesia facial (reduced sense of touch or sensation on face)
Hypoaesthesia oral (reduced sense of touch or sensation in mouth)

30-39:

Drug ineffective
Nervousness
Nightmare (unpleasant dream)
Palpitations (feelings or sensations that your heart is pounding or racing)
Application site erythema (redness of the skin at application site)

40-49:

Nausea (feeling of having an urge to vomit)
Accident
Affective disorder (mental disorder)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Asthenia (weakness)
Cellulitis (infection under the skin)
Constipation
Decreased appetite

50-59:

Ovarian cyst (fluid filled sac of the ovary)
Pain
Pain in extremity
Pain in jaw
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Pelvic mass
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Polycystic ovaries (cysts in the ovaries that occurs when the follicle stops developing)
Productive cough

60+:

Abdominal discomfort
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Pharyngeal neoplasm (pharyngeal tumour)
Skin discolouration (change of skin colour)
Vomiting
Weight decreased
Lower limb fracture
Upper limb fracture
Ageusia (loss of taste functions of the tongue)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the existing conditions these people have? *

Thyroid Diseases: 11 people, 39.29%
Pain: 9 people, 32.14%
High Blood Cholesterol: 8 people, 28.57%
Sleep Disorder: 6 people, 21.43%
Urinary Tract Infection: 4 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.71%
Insomnia (sleeplessness): 3 people, 10.71%
Asthma: 3 people, 10.71%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 10.71%
Stress And Anxiety: 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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