Levoxyl and Protamine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Protamine sulfate (protamine sulfate). Common drug interactions include anxiety among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Protamine sulfate. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Protamine sulfate?

Protamine sulfate has active ingredients of protamine sulfate. eHealthMe is studying from 3,292 Protamine sulfate users. Check the latest studies of Protamine sulfate.

On Aug, 10, 2026

20 people who take Levoxyl and Protamine sulfate together, and have interactions are studied.

Levoxyl and Protamine sulfate drug interactions.

What are the common drug interactions of Levoxyl and Protamine Sulfate, by gender? *:

female:

Anxiety
Pain
Renal failure (kidney dysfunction)
Fear
Emotional distress
Renal injury (kidney injury)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Injury
Renal impairment (severely reduced kidney function)
Depression

male:

Anxiety
Pain
Injury
Death
Depression
Nervousness
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug screen positive
Organ failure

What are the common drug interactions of Levoxyl and Protamine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anxiety
Injury
Pain
Renal failure (kidney dysfunction)
Emotional distress
Fear
Multi-organ failure (multisystem organ failure)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Renal impairment (severely reduced kidney function)

60+:

Anxiety
Pain
Injury
Depression
Death
Nervousness
Anaphylactic reaction (serious allergic reaction)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cardiac arrest
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Diabetes: 2 people, 10.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 10.00%
Chronic Renal Failure (kidney failure): 2 people, 10.00%
Depression: 1 person, 5.00%
Back Pain: 1 person, 5.00%
Blood Pressure Systolic Decreased: 1 person, 5.00%
Breast Cancer: 1 person, 5.00%
Chest Pain: 1 person, 5.00%
Coagulation Time Prolonged: 1 person, 5.00%
Post Procedural Haemorrhage (post procedural bleeding): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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