Levoxyl and Protopic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Protopic (tacrolimus). Common drug interactions include femur fracture among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Protopic. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

On Jul, 13, 2026

14 people who take Levoxyl and Protopic together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Protopic, by gender? *:

female:

Femur fracture
Gastroenteritis helicobacter (inflammation of stomach and intestine caused by helicobacter infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Groin pain
Heart valve incompetence (heart's valves do not work correctly)
Hyperkalaemia (damage to or disease of the kidney)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing

male:

Abdominal pain
Abdominal pain upper
Dizziness
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Extranodal marginal zone b-cell lymphoma (malt type) (cancer originating from b cells in the marginal zone of the malt)
Fall
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)

What are the common drug interactions of Levoxyl and Protopic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Dermatitis psoriasiform (large white or silver flakes on the skin)
Drug eruption (adverse drug reaction of the skin)
Endocarditis staphylococcal (an inflammation of the inner layer of the heart by staphylococcal bacterial infection)

50-59:

n/a

60+:

Pain in extremity
Abdominal pain
Diarrhoea
Disease recurrence
Dizziness
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Extranodal marginal zone b-cell lymphoma (malt type) (cancer originating from b cells in the marginal zone of the malt)
Fall

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 6 people, 42.86%
Pain: 3 people, 21.43%
Vitiligo (pigment is lost from areas of the skin): 2 people, 14.29%
Dermatitis Allergic (inflammation of the skin due allergic reaction): 2 people, 14.29%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 7.14%
Ventricular Arrhythmia (problem with the rate or rhythm of the heartbeat): 1 person, 7.14%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 7.14%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 7.14%
Migraine With Aura (headache with vision weakness): 1 person, 7.14%
Migraine (headache): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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