Levoxyl and Tykerb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Tykerb (lapatinib ditosylate). Common drug interactions include diarrhoea among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Tykerb. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

On Jul, 16, 2026

19 people who take Levoxyl and Tykerb together, and have interactions are studied.

What are the common drug interactions of Levoxyl and Tykerb, by gender? *:

female:

Diarrhoea
International normalised ratio increased
Oedema peripheral (superficial swelling)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin ulcer
Urine flow decreased
Vomiting
Adverse event
Decreased appetite
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)

male:

Death

What are the common drug interactions of Levoxyl and Tykerb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
International normalised ratio increased
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting

40-49:

Adverse event
Death
Diarrhoea
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Viral infection

50-59:

Diarrhoea
Death
Dry skin
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Onychomadesis (a periodic idiopathic shedding of the nails)
Rash
Skin chapped
Stomatitis (inflammation of mucous membrane of mouth)

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Dysgeusia (disorder of the sense of taste)
Folliculitis (infection of hair root)
Mouth ulceration (mouth ulcers)
Muscular weakness (muscle weakness)
Oedema peripheral (superficial swelling)
Pain
Pharyngolaryngeal pain
Rash pruritic (redness with itching)

What are the existing conditions these people have? *

Simple Partial Seizures (seizures which affect only a small region of the brain): 1 person, 5.26%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 5.26%
High Blood Pressure: 1 person, 5.26%
High Blood Cholesterol: 1 person, 5.26%
Diabetes: 1 person, 5.26%
Adverse Drug Reaction: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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