Levoxyl and Zegerid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Levoxyl (levothyroxine sodium) and Zegerid (omeprazole; sodium bicarbonate). Common drug interactions include anaemia among females and dyspepsia among males.

The phase IV clinical study analyzes what interactions people have when they take Levoxyl and Zegerid. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Levoxyl?

Levoxyl has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 25,178 Levoxyl users. Check the latest studies of Levoxyl.

What is Zegerid?

Zegerid has active ingredients of omeprazole; sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 3,220 Zegerid users. Check the latest studies of Zegerid.



On Jul, 18, 2026

13 people who take Levoxyl and Zegerid together, and have interactions are studied.

Levoxyl and Zegerid drug interactions.

What are the common drug interactions of Levoxyl and Zegerid, by gender? *:

female:

  1. Anaemia (lack of blood)
  2. Nausea (feeling of having an urge to vomit)
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Dyspnoea (difficult or laboured respiration)
  5. Gastritis (inflammation of stomach)
  6. Insomnia (sleeplessness)
  7. Abdominal pain upper
  8. Adverse drug reaction
  9. Asthenia (weakness)
  10. Asthma

male:

  1. Dyspepsia (indigestion)
  2. Fatigue (feeling of tiredness)
  3. Headache (pain in head)
  4. Hyperacusis (disorder in loudness perception)
  5. Increased appetite
  6. Insomnia (sleeplessness)
  7. Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
  8. Tinnitus (a ringing in the ears)
  9. Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)
  10. Vision blurred

What are the common drug interactions of Levoxyl and Zegerid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Diarrhoea
  2. Hypersensitivity

40-49:

  1. Abdominal pain upper
  2. Adverse drug reaction
  3. Asthenia (weakness)
  4. Decreased appetite
  5. Dependence
  6. Depression
  7. Device expulsion
  8. Dyskinesia (abnormality or impairment of voluntary movement)
  9. Dyspepsia (indigestion)
  10. Dyspnoea (difficult or laboured respiration)

50-59:

  1. Dyspnoea (difficult or laboured respiration)
  2. Hot flush (sudden feelings of heat)
  3. Hyperhidrosis (abnormally increased sweating)
  4. Insomnia (sleeplessness)
  5. Pain in extremity
  6. Palpitations (feelings or sensations that your heart is pounding or racing)
  7. Gastritis (inflammation of stomach)
  8. Nausea (feeling of having an urge to vomit)
  9. Asthma
  10. Back pain

60+:

  1. Anaemia (lack of blood)
  2. Thrombocytopenia (decrease of platelets in blood)
  3. Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

  1. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 38.46%
  2. Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 1 person, 7.69%
  3. Thyroid Diseases: 1 person, 7.69%
  4. Pain In Extremity: 1 person, 7.69%
  5. Indigestion: 1 person, 7.69%
  6. High Blood Cholesterol: 1 person, 7.69%
  7. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 7.69%
  8. Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 7.69%
  9. Dry Eyes (lack of adequate tears): 1 person, 7.69%
  10. Depression: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Levoxyl and Zegerid?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Levoxyl and Zegerid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Levoxyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zegerid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Levoxyl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zegerid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on levothyroxine sodium and omeprazole; sodium bicarbonate (the active ingredients of Levoxyl and Zegerid, respectively), and Levoxyl and Zegerid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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