Lexapro and Promethazine dm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lexapro (escitalopram oxalate) and Promethazine dm (dextromethorphan hydrobromide; promethazine hydrochloride). Common drug interactions include chronic kidney disease among females.

The phase IV clinical study analyzes what interactions people have when they take Lexapro and Promethazine dm. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

What is Promethazine dm?

Promethazine dm has active ingredients of dextromethorphan hydrobromide; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 624 Promethazine dm users. Check the latest studies of Promethazine dm.



On Jul, 20, 2026

11 people who take Lexapro and Promethazine dm together, and have interactions are studied.

Lexapro and Promethazine dm drug interactions.

What are the common drug interactions of Lexapro and Promethazine Dm, by gender? *:

female:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Diabetic coma
  4. Diabetic complication
  5. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  6. Hyperglycaemia (high blood sugar)
  7. Impaired healing
  8. Type 1 diabetes mellitus
  9. Type 2 diabetes mellitus
  10. Renal failure (kidney dysfunction)

male:

n/a

What are the common drug interactions of Lexapro and Promethazine Dm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Fall
  2. Foot fracture
  3. Lower limb fracture
  4. Impaired healing

20-29:

n/a

30-39:

n/a

40-49:

  1. Hyperglycaemia (high blood sugar)
  2. Type 1 diabetes mellitus
  3. Type 2 diabetes mellitus
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Adverse event
  6. Back pain
  7. Diabetes mellitus inadequate control
  8. Diabetic coma
  9. Diabetic complication
  10. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

50-59:

n/a

60+:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

  1. Pain: 5 people, 45.45%
  2. Muscle Spasms (muscle contraction): 5 people, 45.45%
  3. Stress And Anxiety: 3 people, 27.27%
  4. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 27.27%
  5. Migraine (headache): 3 people, 27.27%
  6. The Flu (the flu is caused by an influenza virus): 2 people, 18.18%
  7. Asthma: 2 people, 18.18%
  8. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 18.18%
  9. Constipation: 2 people, 18.18%
  10. Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Lexapro and Promethazine dm?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lexapro and Promethazine dm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lexapro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Promethazine dm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lexapro and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Promethazine dm and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on escitalopram oxalate and dextromethorphan hydrobromide; promethazine hydrochloride (the active ingredients of Lexapro and Promethazine dm, respectively), and Lexapro and Promethazine dm (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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