Lexapro and Wakix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lexapro (escitalopram oxalate) and Wakix (pitolisant hydrochloride). Common drug interactions include pelvic fracture among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Lexapro and Wakix. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

On Jul, 27, 2026

65 people who take Lexapro and Wakix together, and have interactions are studied.

What are the common drug interactions of Lexapro and Wakix, by gender? *:

female:

Pelvic fracture
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Abdominal distension
Agitation (state of anxiety or nervous excitement)
Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Back pain
Bipolar disorder (mood disorder)

male:

Drug ineffective
Dizziness
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Fatigue (feeling of tiredness)
Abnormal sleep-related event
Head injury
Loss of consciousness
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Nausea (feeling of having an urge to vomit)
Sleep disorder

What are the common drug interactions of Lexapro and Wakix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypoacusis (loss of hearing)
Pelvic fracture
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)

20-29:

Drug ineffective
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Hunger
Initial insomnia (feeling of inadequate or poor-quality sleep)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Poor quality sleep
Retching (strong involuntary effort to vomit)

30-39:

Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dizziness
Feeling drunk
Hepatic enzyme increased
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nightmare (unpleasant dream)
Panic attack
Photopsia (presence of perceived flashes of light)
Somnolence (a state of near-sleep, a strong desire for sleep)

40-49:

Fatigue (feeling of tiredness)
Abnormal sleep-related event
Back pain
Chest pain
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Sleep disorder
Vomiting
Abdominal discomfort
Abnormal dreams
Blood potassium decreased

50-59:

Blood sodium decreased
Drug ineffective
Somnolence (a state of near-sleep, a strong desire for sleep)
Chronic fatigue syndrome (disorder that causes extreme fatigue)

60+:

Abdominal discomfort
Headache (pain in head)
Tremor (trembling or shaking movements in one or more parts of your body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fall
Nephrolithiasis (calculi in the kidneys)
Rib fracture

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 63 people, 96.92%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 40 people, 61.54%
Drowsiness: 18 people, 27.69%
Stress And Anxiety: 9 people, 13.85%

* Approximation only. Some reports may have incomplete information.

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