Lexapro and Zestoretic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lexapro (escitalopram oxalate) and Zestoretic (hydrochlorothiazide; lisinopril). Common drug interactions include arthralgia among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Lexapro and Zestoretic. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Lexapro?

Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,464 Lexapro users. Check the latest studies of Lexapro.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

On Jul, 17, 2026

78 people who take Lexapro and Zestoretic together, and have interactions are studied.

Lexapro and Zestoretic drug interactions.

What are the common drug interactions of Lexapro and Zestoretic, by gender? *:

female:

Arthralgia (joint pain)
Cystitis (inflammation of the wall of the bladder)
Dyspnoea (difficult or laboured respiration)
Injection site reaction
Nephrogenic anaemia (anaemia due to kidney disease)
Confusional state
Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Bladder discomfort
Candidiasis (candidiasis or thrush is a fungal infection)

male:

Asthenia (weakness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Anaemia (lack of blood)
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Cholecystitis chronic (long lasting infection of gallbladder)
Compression fracture (fracture due to pressure caused by injury)
Constipation
Decreased appetite

What are the common drug interactions of Lexapro and Zestoretic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pain
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Blood albumin decreased
Blood alkaline phosphatase increased
Blood calcium decreased
Blood chloride decreased
Blood creatinine decreased
Blood glucose increased
Blood lactate dehydrogenase increased

40-49:

Hypokalaemia (low potassium)
Dysarthria (speech disorder)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Headache (pain in head)
Asthenia (weakness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Renal failure acute (rapid kidney dysfunction)
Type 2 diabetes mellitus
Confusional state
Arthralgia (joint pain)

50-59:

Arthralgia (joint pain)
Bone disorder
Candidiasis (candidiasis or thrush is a fungal infection)
Cellulitis (infection under the skin)
Cholecystitis chronic (long lasting infection of gallbladder)
Compression fracture (fracture due to pressure caused by injury)
Confusional state
Constipation
Decreased appetite
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

60+:

Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Abdominal infection
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Confusional state
Decreased appetite

What are the existing conditions these people have? *

Menopausal Symptoms: 15 people, 19.23%
Insomnia (sleeplessness): 13 people, 16.67%
Bipolar Disorder (mood disorder): 11 people, 14.10%
Post-Traumatic Stress Disorder: 10 people, 12.82%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 12.82%
Seasonal Allergy (allergic condition due to certain season): 9 people, 11.54%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 9 people, 11.54%
High Blood Cholesterol: 8 people, 10.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 7.69%
Stress And Anxiety: 4 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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