Librium and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Librium (chlordiazepoxide hydrochloride) and Ultram (tramadol hydrochloride). Common drug interactions include blood prolactin increased among females and application site pruritus among males.

The phase IV clinical study analyzes what interactions people have when they take Librium and Ultram. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

52 people who take Librium and Ultram together, and have interactions are studied.

What are the common drug interactions of Librium and Ultram, by gender? *:

female:

Blood prolactin increased
Cachexia (loss of weight)
Cardiac arrest
Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Decreased appetite
Drug ineffective

male:

Application site pruritus (application site severe itching of the skin)
Fear
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arrhythmia (irregular heartbeat)
Arteriosclerosis (thickening and hardening of arteries)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Aspartate aminotransferase increased
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Balance disorder
Blood alkaline phosphatase nos increased

What are the common drug interactions of Librium and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Asthma
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depressed level of consciousness
Depression
Drug abuser
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysarthria (speech disorder)

40-49:

Mycobacterial infection
Pneumonia
Cough
Productive cough
Bone pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Tuberculosis (a bacterial infection by mycobacterium tuberculosis)
Type 2 diabetes mellitus
Weight decreased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

50-59:

Bradycardia (abnormally slow heart action)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Drug effect decreased
Drug intolerance (drug sensitivity)
Fall
Fatigue (feeling of tiredness)
Foot fracture

60+:

Weight decreased
Cardiac failure congestive
Cachexia (loss of weight)
Cardiac arrest
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Decreased appetite
Dizziness
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 17.31%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 17.31%
Depression: 5 people, 9.62%
High Blood Cholesterol: 4 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.77%
Muscle Aches (muscle pain): 3 people, 5.77%
Migraine (headache): 3 people, 5.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.77%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 5.77%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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