Lidex and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lidex (fluocinonide) and Profen (ibuprofen). Common drug interactions include injury among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Lidex and Profen. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Lidex?

Lidex has active ingredients of fluocinonide. eHealthMe is studying from 1,039 Lidex users. Check the latest studies of Lidex.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Aug, 09, 2026

60 people who take Lidex and Profen together, and have interactions are studied.

What are the common drug interactions of Lidex and Profen, by gender? *:

female:

Injury
Rash
Depression
Hypercholesterolaemia (high levels of cholesterol in the blood)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Spinal osteoarthritis (joint cartilage loss in spine)
Swelling
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Urticaria (rash of round, red welts on the skin that itch intensely)
Bone disorder

male:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Groin pain
Ileitis (inflammation of the ileum)
Inflammatory bowel disease
Irritable bowel syndrome
Multi-organ disorder (multiple organ disease)
Anal haemorrhage

What are the common drug interactions of Lidex and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Activated partial thromboplastin time prolonged
Blood fibrinogen decreased
Blood pressure inadequately controlled
Cardiac arrest
Coagulopathy (blood's ability to clot is impaired)
Colitis (inflammation of colon)
Cytomegalovirus test positive
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic failure (liver failure)
Infective glossitis (tongue can become inflamed or infected)

10-19:

Abscess jaw (tooth abscess or root abscess)
Anxiety
Arthralgia (joint pain)
Arthropathy
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Balance disorder
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

20-29:

Abdominal pain upper
Anaemia (lack of blood)
Arthralgia (joint pain)
Cardiac disorder
Chest pain
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Decreased appetite
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

30-39:

Headache (pain in head)
Ageusia (loss of taste functions of the tongue)
Anosmia (partial or complete loss of the sense of smell)
Arthralgia (joint pain)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug hypersensitivity
Dysaesthesia (abnormal sensation)
Foetal hypokinesia (decreased bodily movement of foetus)
Gait disturbance

40-49:

Abscess (pus)
Cellulitis (infection under the skin)
Epistaxis (bleed from the nose)
Fall
Foot fracture
Ligament sprain (ligament stretched)
Localised infection (infection at the single location)
Staphylococcal infection (an infection with staphylococcus bacteria)
Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

Granuloma (a small area of inflammation due to tissue injury)
Hepatic function abnormal
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Injection site bruising
Injection site mass
Injection site pruritus (severe itching at injection site)
Injection site reaction
Soft tissue necrosis (death of soft tissue)
Thrombosis (formation of a blood clot inside a blood vessel)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Depression
Cough
Decreased appetite
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Enteritis (inflammation of the small intestine)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Insomnia (sleeplessness)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Nasal polyps (masses that develop in the lining of the nose)

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 11 people, 18.33%
Sinusitis (inflammation of sinus): 9 people, 15.00%
Rashes (redness): 9 people, 15.00%
Allergic Sinusitis: 9 people, 15.00%
Gastric Ulcer (stomach ulcer): 9 people, 15.00%
Nausea (feeling of having an urge to vomit): 8 people, 13.33%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 11.67%
Nausea And Vomiting: 7 people, 11.67%
High Blood Pressure: 7 people, 11.67%
Headache (pain in head): 7 people, 11.67%

* Approximation only. Some reports may have incomplete information.

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