Lidoderm and Duloxetine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lidoderm (lidocaine) and Duloxetine hydrochloride (duloxetine hydrochloride). Common drug interactions include nausea among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Lidoderm and Duloxetine hydrochloride. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Lidoderm?

Lidoderm has active ingredients of lidocaine. It is often used in pain. eHealthMe is studying from 10,524 Lidoderm users. Check the latest studies of Lidoderm.

What is Duloxetine hydrochloride?

Duloxetine hydrochloride has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 17,410 Duloxetine hydrochloride users. Check the latest studies of Duloxetine hydrochloride.

On Jul, 12, 2026

45 people who take Lidoderm and Duloxetine hydrochloride together, and have interactions are studied.

Lidoderm and Duloxetine hydrochloride drug interactions.

What are the common drug interactions of Lidoderm and Duloxetine Hydrochloride, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Blood pressure increased
Rash
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Drug hypersensitivity
Fall
Poor venous access
Urinary tract infection

male:

Arthralgia (joint pain)
Abasia (inability to walk)
Constipation
Fatigue (feeling of tiredness)
Hip fracture
Lower respiratory tract infection
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Sedation
Weight increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

What are the common drug interactions of Lidoderm and Duloxetine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abasia (inability to walk)
Arthralgia (joint pain)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Femur fracture
Pain in extremity
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Cardiac disorder

10-19:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Head injury
Headache (pain in head)
Infusion related reaction
Nausea (feeling of having an urge to vomit)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting

20-29:

Arthropathy
Dyspnoea (difficult or laboured respiration)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Hellp syndrome (life-threatening pregnancy complication)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Road traffic accident

30-39:

Adenoidal disorder (pharyngeal tonsil disorder)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Bipolar disorder (mood disorder)
Contusion (a type of hematoma of tissue in which capillaries)
Femur fracture
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Obesity (having too much body fat)
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Alanine aminotransferase increased
Ankle fracture
Arthralgia (joint pain)
Aspartate aminotransferase increased
Back injury
Blood sodium decreased
Blood uric acid decreased
Chest pain
Cough
Diarrhoea

50-59:

Nervousness
Poor venous access
Regressive behaviour (immature behaviour to ventilate feelings)
Renal injury (kidney injury)
Tremor (trembling or shaking movements in one or more parts of your body)
Disease recurrence
Abdominal pain upper
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood cholesterol increased

60+:

Fall
Arthralgia (joint pain)
Eye infection
Fatigue (feeling of tiredness)
Full blood count decreased
Gangrene (body tissue dies)
Limb discomfort (discomfort in leg)
Pain in extremity
Sinus disorder (disease of sinus)
Vein discolouration

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 17.78%
Insomnia (sleeplessness): 8 people, 17.78%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 15.56%
Constipation: 5 people, 11.11%
Nausea (feeling of having an urge to vomit): 5 people, 11.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.11%
Migraine (headache): 5 people, 11.11%
High Blood Pressure: 5 people, 11.11%
Stress And Anxiety: 4 people, 8.89%
Immunodeficiency Common Variable: 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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