Lidoderm and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lidoderm (lidocaine) and Opsumit (macitentan). Common drug interactions include haematuria among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lidoderm and Opsumit. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Lidoderm?

Lidoderm has active ingredients of lidocaine. It is often used in pain. eHealthMe is studying from 10,524 Lidoderm users. Check the latest studies of Lidoderm.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

36 people who take Lidoderm and Opsumit together, and have interactions are studied.

What are the common drug interactions of Lidoderm and Opsumit, by gender? *:

female:

Haematuria (presence of blood in urine)
Haemoglobin decreased
Hallucination (an experience involving the perception of something not present)
Infusion site pain
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Oxygen saturation decreased
Pruritus (severe itching of the skin)
Pyuria (a condition of urine containing pus)
Small intestinal obstruction (blockage in small intestine)

male:

Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Pain in extremity

What are the common drug interactions of Lidoderm and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective
Fatigue (feeling of tiredness)
Infusion site pruritus (severe itching at infusion site)
Oxygen consumption increased
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

20-29:

n/a

30-39:

Confusional state
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain
Nausea (feeling of having an urge to vomit)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)
Skin wound
Vomiting

40-49:

Adverse event
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood pressure increased
Cardioactive drug level decreased
Catheter site erythema (redness of skin at catheter site)
Catheter site haemorrhage (bleeding at catheter site)
Chest pain

50-59:

Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Decreased appetite
Flushing (the warm, red condition of human skin)
Myalgia (muscle pain)
Nasopharyngitis (inflammation of the nasopharynx)
Oedema (fluid collection in tissue)
Vomiting
Dizziness
Insomnia (sleeplessness)

60+:

Dyspnoea (difficult or laboured respiration)
Diarrhoea
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pyrexia (fever)
Abdominal hernia obstructive (abdominal hernia causing a blockage)
Asthenia (weakness)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cystitis (inflammation of the wall of the bladder)
Delirium (wild excitement)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 35 people, 97.22%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 4 people, 11.11%
Diarrhea: 3 people, 8.33%
Stress And Anxiety: 2 people, 5.56%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 5.56%
Nausea And Vomiting: 2 people, 5.56%
Nausea (feeling of having an urge to vomit): 2 people, 5.56%
Lung Disorder (lung disease): 2 people, 5.56%
Infection: 2 people, 5.56%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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