Linaclotide and Dexilant drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linaclotide (linaclotide) and Dexilant (dexlansoprazole). Common drug interactions include atrioventricular block among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Linaclotide and Dexilant. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Linaclotide?

Linaclotide has active ingredients of linaclotide. eHealthMe is studying from 2,197 Linaclotide users. Check the latest studies of Linaclotide.

What is Dexilant?

Dexilant has active ingredients of dexlansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 57,103 Dexilant users. Check the latest studies of Dexilant.

On Jul, 31, 2026

50 people who take Linaclotide and Dexilant together, and have interactions are studied.

Linaclotide and Dexilant drug interactions.

What are the common drug interactions of Linaclotide and Dexilant, by gender? *:

female:

Atrioventricular block (heart block)
Attention deficit/hyperactivity disorder
Back pain
Blood pressure increased
Burning sensation
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Contrast media allergy (reaction associated with the use of intravenous contrast material during radiology)
Cough
Decreased appetite
Dehydration (dryness resulting from the removal of water)

male:

Constipation
Nausea (feeling of having an urge to vomit)
Faecal volume increased
Faeces hard
Lip injury
Mobility decreased (ability to move is reduced)
Vomiting
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Drug ineffective

What are the common drug interactions of Linaclotide and Dexilant, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Migraine (headache)

30-39:

Abdominal distension
Abdominal pain
Abnormal dreams
Allergy to plants
Anxiety
Attention deficit/hyperactivity disorder
Blood pressure increased
Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Constipation
Cough

40-49:

Renal failure (kidney dysfunction)
Abdominal discomfort
Abdominal pain
Back pain
Diarrhoea
Headache (pain in head)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Intestinal obstruction
Nausea (feeling of having an urge to vomit)
Neck pain

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Abdominal distension
Alopecia (absence of hair from areas of the body)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Dizziness
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Migraine (headache)
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Constipation
Headache (pain in head)
Dizziness
Fall
Influenza
Intestinal obstruction
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Faecal volume increased
Faeces hard

What are the existing conditions these people have? *

Constipation: 15 people, 30.00%
Pain: 10 people, 20.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 16.00%
Irritable Bowel Syndrome: 8 people, 16.00%
Hormone Level Abnormal: 5 people, 10.00%
Gastrointestinal Stromal Tumor: 5 people, 10.00%
Infection: 5 people, 10.00%
Muscle Spasms (muscle contraction): 5 people, 10.00%
Inflammation: 4 people, 8.00%
Cardiac Disorder: 4 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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