Linzess and Lubiprostone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Lubiprostone (lubiprostone). Common drug interactions include pain among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Lubiprostone. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Lubiprostone?

Lubiprostone has active ingredients of lubiprostone. eHealthMe is studying from 957 Lubiprostone users. Check the latest studies of Lubiprostone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

41 people who take Linzess and Lubiprostone together, and have interactions are studied.

Linzess and Lubiprostone drug interactions.

What are the common drug interactions of Linzess and Lubiprostone, by gender? *:

female:

Pain
Headache (pain in head)
Diarrhoea
Dizziness
Drug intolerance (drug sensitivity)
Fall
Fungal infection
Hospitalisation
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Migraine (headache)

male:

Asthenia (weakness)
Angiopathy (generic term for a disease of the blood vessels)
Fatigue (feeling of tiredness)
Hypersensitivity
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint stiffness
Snoring
Throat tightness
Anxiety
Arthralgia (joint pain)

What are the common drug interactions of Linzess and Lubiprostone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Chest pain
Depression
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypersensitivity

30-39:

Neuropathy peripheral (surface nerve damage)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Regurgitation (expulsion of material)
Road traffic accident
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tendonitis (a condition that causes pain and swelling of tendons)
Vertigo
Allergy to arthropod bite
Asthenia (weakness)
Asthma

40-49:

Fungal infection
Headache (pain in head)
Pain
Abdominal pain upper
Pancreatitis (inflammation of pancreas)
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Abdominal pain
Adverse event

50-59:

Abdominal distension
Abdominal pain
Ageusia (loss of taste functions of the tongue)
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dysgeusia (disorder of the sense of taste)
Eye inflammation
Headache (pain in head)
Hypoglycaemia (deficiency of glucose in the bloodstream)

60+:

Hospitalisation
Alanine aminotransferase increased
Hypopnoea (decrease in the breathing rate)
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Retching (strong involuntary effort to vomit)
Tendonitis (a condition that causes pain and swelling of tendons)
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary retention (the inability to completely or partially empty the bladder)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 6 people, 14.63%
Migraine (headache): 5 people, 12.20%
Drowsiness: 5 people, 12.20%
Pain: 4 people, 9.76%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 4 people, 9.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 9.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 9.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 9.76%
Impaired Gastric Emptying: 4 people, 9.76%
Depression: 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

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