Linzess and Oxervate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Oxervate (cenegermin-bkbj). Common drug interactions include eye pain among females and eye pain among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Oxervate. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Oxervate?

Oxervate has active ingredients of cenegermin-bkbj. eHealthMe is studying from 7,219 Oxervate users. Check the latest studies of Oxervate.

On Jul, 19, 2026

36 people who take Linzess and Oxervate together, and have interactions are studied.

What are the common drug interactions of Linzess and Oxervate, by gender? *:

female:

Eye pain
Eye irritation
Eyelid pain
Headache (pain in head)
Eye discharge
Foreign body sensation in eyes (feeling of something in eye)
Lacrimation increased
Nausea (feeling of having an urge to vomit)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Stomatitis (inflammation of mucous membrane of mouth)

male:

Eye pain
Drug ineffective
Oropharyngeal pain
Pneumonia
Vision blurred
Dyspnoea (difficult or laboured respiration)
Photophobia (extreme sensitivity to light)
Abnormal sensation in eye
Eyelid irritation
Corneal deposits

What are the common drug interactions of Linzess and Oxervate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Eyelid pain
Headache (pain in head)

50-59:

Eye pain
Vomiting
Foreign body sensation in eyes (feeling of something in eye)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pyrexia (fever)

60+:

Eye irritation
Eye pain
Tongue ulceration (ulcers on tongue)
Abnormal sensation in eye
Eyelid pain
Foreign body sensation in eyes (feeling of something in eye)
Dacryostenosis acquired (obstruction of the nasolacrimal duct-acquired)
Photophobia (extreme sensitivity to light)
Dry eye (lack of adequate tears)
Eye infection

What are the existing conditions these people have? *

Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 34 people, 94.44%
Hypoaesthesia Eye (reduced sense of touch or sensation on eyes): 5 people, 13.89%
Ulcerative Keratitis (ulcerative inflammation of the cornea): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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