Lioresal and Levaquin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lioresal (baclofen) and Levaquin (levofloxacin). Common drug interactions include decreased appetite among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Lioresal and Levaquin. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Lioresal?

Lioresal has active ingredients of baclofen. It is often used in multiple sclerosis. eHealthMe is studying from 20,572 Lioresal users. Check the latest studies of Lioresal.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

On Jul, 20, 2026

98 people who take Lioresal and Levaquin together, and have interactions are studied.

Lioresal and Levaquin drug interactions.

What are the common drug interactions of Lioresal and Levaquin, by gender? *:

female:

Decreased appetite
Deformity (disfigurement)
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dizziness
Dyspepsia (indigestion)
Emotional distress
Epistaxis (bleed from the nose)
Injury
Intervertebral disc protrusion (spinal disc protrusion)

male:

Depression
Pain
Cellulitis (infection under the skin)
Dysstasia (difficulty in standing)
Insomnia (sleeplessness)
Failure to thrive (inadequate weight gain and physical growth in children)
Hypertension (high blood pressure)
Injury
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Abnormal behaviour

What are the common drug interactions of Lioresal and Levaquin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
General physical health deterioration (weak health status)
Injury
Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)

20-29:

Abdominal pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Anaemia (lack of blood)
Anorectal varices haemorrhage (dilation of collateral submucousal vessels due to backflow in the veins of the rectum with massive bleeding)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood lactic acid increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Coagulopathy (blood's ability to clot is impaired)
Contusion (a type of hematoma of tissue in which capillaries)

30-39:

Anxiety
Depression
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Tendon rupture (tear of tendon)
Tendonitis (a condition that causes pain and swelling of tendons)
Therapeutic response decreased (less preventive response)

40-49:

Pyrexia (fever)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Burning sensation
Diplopia (double vision)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain in extremity
Flushing (the warm, red condition of human skin)
Muscular weakness (muscle weakness)
Pain of skin
Pruritus (severe itching of the skin)

50-59:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis of jaw (death of bone of jaw)
Spinal column stenosis (narrowing of spinal column)
Decreased appetite
Deformity (disfigurement)
Injury
Neuralgia (pain in one or more nerves)
Renal failure (kidney dysfunction)
Insomnia (sleeplessness)
Neck pain

60+:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Irritability
Cardiac failure congestive
Cellulitis (infection under the skin)
Dyspnoea (difficult or laboured respiration)
Ear pain
Febrile neutropenia (fever with reduced white blood cells)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Injury
Lung adenocarcinoma (a form of non-small cell lung cancer)

What are the existing conditions these people have? *

Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 25 people, 25.51%
Multiple Myeloma (cancer of the plasma cells): 21 people, 21.43%
Pain: 18 people, 18.37%
Constipation: 17 people, 17.35%
Stress And Anxiety: 14 people, 14.29%
Nausea (feeling of having an urge to vomit): 14 people, 14.29%
High Blood Pressure: 12 people, 12.24%
Depression: 10 people, 10.20%
Muscle Spasms (muscle contraction): 10 people, 10.20%
Diarrhea: 9 people, 9.18%

* Approximation only. Some reports may have incomplete information.

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