Lipitor and Synthroid drug interactions - from FDA reports

Summary

Drug interactions are reported among people who take Lipitor and Synthroid together. This study is created by eHealthMe based on reports of 13,108 people who take Lipitor and Synthroid from FDA, and is updated regularly.



What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on atorvastatin calcium and levothyroxine sodium (the active ingredients of Lipitor and Synthroid, respectively), and Lipitor and Synthroid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.

What is Lipitor?

Lipitor has active ingredients of atorvastatin calcium. It is often used in high blood cholesterol. (latest outcomes from Lipitor 208,540 users)

What is Synthroid?

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 170,727 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.


On Feb, 23, 2019

13,108 people who take Lipitor, Synthroid are studied.


Number of reports submitted per year:

Lipitor and Synthroid drug interactions.

Most common drug interactions over time *:

< 1 month:
  1. Headache (pain in head)
  2. Myalgia (muscle pain)
  3. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  4. Dyspnoea (difficult or laboured respiration)
  5. Insomnia (sleeplessness)
  6. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  7. Muscular weakness (muscle weakness)
  8. Arthralgia (joint pain)
  9. Cerebral haemorrhage (bleeding within the brain)
  10. Dizziness
1 - 6 months:
  1. Fatigue (feeling of tiredness)
  2. Myalgia (muscle pain)
  3. Pain in extremity
  4. Headache (pain in head)
  5. Arthralgia (joint pain)
  6. Dyspnoea (difficult or laboured respiration)
  7. Rash
  8. Nausea (feeling of having an urge to vomit)
  9. Oedema peripheral (superficial swelling)
  10. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
6 - 12 months:
  1. Myalgia (muscle pain)
  2. Type 2 diabetes mellitus
  3. Headache (pain in head)
  4. Chronic kidney disease
  5. Death
  6. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  7. Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
  8. Hepatic enzyme increased
  9. Diarrhoea
  10. Dizziness
1 - 2 years:
  1. Depression
  2. Chest pain
  3. Headache (pain in head)
  4. Pain in extremity
  5. Fatigue (feeling of tiredness)
  6. Arthralgia (joint pain)
  7. Fall
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Myalgia (muscle pain)
  10. Renal failure (kidney dysfunction)
2 - 5 years:
  1. Fatigue (feeling of tiredness)
  2. Myalgia (muscle pain)
  3. Gait disturbance
  4. Back pain
  5. Pain
  6. Arthralgia (joint pain)
  7. Muscular weakness (muscle weakness)
  8. Myopathy (a muscular disease in which the muscle fibres do not function)
  9. Nausea (feeling of having an urge to vomit)
  10. Dyspnoea (difficult or laboured respiration)
5 - 10 years:
  1. Pain
  2. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  3. Type 2 diabetes mellitus
  4. Chest pain
  5. Dyspnoea (difficult or laboured respiration)
  6. Hypotension (abnormally low blood pressure)
  7. Myalgia (muscle pain)
  8. Pain in extremity
  9. Palpitations (feelings or sensations that your heart is pounding or racing)
  10. Weight increased
10+ years:
  1. Pain in extremity
  2. Fall
  3. Adjustment disorder with anxiety
  4. Atrophy (wasting away of a part of the body)
  5. Blood disorder
  6. Body temperature increased
  7. Bone disorder
  8. Dysphagia (condition in which swallowing is difficult or painful)
  9. Dysthymic disorder (mild chronic depression disorder)
  10. Eye infection
not specified:
  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Dyspnoea (difficult or laboured respiration)
  4. Diarrhoea
  5. Pain
  6. Drug ineffective
  7. Asthenia (weakness)
  8. Dizziness
  9. Fall
  10. Headache (pain in head)

Most common drug interactions by gender *:

female:
  1. Fall
  2. Drug ineffective
  3. Headache (pain in head)
  4. Asthenia (weakness)
  5. Arthralgia (joint pain)
  6. Dizziness
  7. Pain in extremity
  8. Vomiting
  9. Anxiety
  10. Myalgia (muscle pain)
male:
  1. Fatigue (feeling of tiredness)
  2. Dyspnoea (difficult or laboured respiration)
  3. Pneumonia
  4. Chest pain
  5. Back pain
  6. Arthralgia (joint pain)
  7. Cough
  8. Anxiety
  9. Fall
  10. Headache (pain in head)

Most common drug interactions by age *:

0-1:
  1. Application site erythema (redness of the skin at application site)
  2. Application site pruritus (application site severe itching of the skin)
  3. Blood pressure diastolic increased
  4. Drug ineffective
  5. Flatulence (flatus expelled through the anus)
  6. Hyperprolactinaemia (abnormally high levels of prolactin in the blood)
  7. Leiomyoma (a noncancerous (benign) tumour made up mostly of smooth muscle cells)
  8. Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
  9. Obesity (a medical condition in which excess body fat)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
2-9:
  1. Abdominal distension
  2. Abdominal pain upper
  3. Accident at work
  4. Angioedema (rapid swelling of the dermis)
  5. Arrhythmia (irregular heartbeat)
  6. Asthenia (weakness)
  7. Back pain
  8. Blood glucose increased
  9. Contusion (a type of hematoma of tissue in which capillaries)
  10. Crying
10-19:
  1. Kidney transplant rejection
  2. Leukopenia (less number of white blood cells in blood)
  3. Pyrexia (fever)
  4. Blood creatinine increased
  5. Diabetic complication
  6. Drug level below therapeutic
  7. Gastroenteritis (inflammation of stomach and intestine)
  8. Haematemesis (vomiting of blood)
  9. Immunosuppressant drug level decreased
  10. Nausea (feeling of having an urge to vomit)
20-29:
  1. Dizziness
  2. Balance disorder
  3. Anxiety
  4. Pulmonary embolism (blockage of the main artery of the lung)
  5. Syncope (loss of consciousness with an inability to maintain postural tone)
  6. Pyrexia (fever)
  7. Anaemia (lack of blood)
  8. Blood creatinine increased
  9. Cough
  10. Depression
30-39:
  1. Fall
  2. Pain in extremity
  3. Spinal column stenosis (narrowing of spinal column)
  4. Asthma
  5. Nausea (feeling of having an urge to vomit)
  6. Vomiting
  7. Choking (mechanical obstruction of the flow of air from the environment into the lungs)
  8. Diarrhoea
  9. Blood potassium decreased
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
40-49:
  1. Pain
  2. Nausea (feeling of having an urge to vomit)
  3. Type 2 diabetes mellitus
  4. Headache (pain in head)
  5. Fatigue (feeling of tiredness)
  6. Anxiety
  7. Chest pain
  8. Arthralgia (joint pain)
  9. Dyspnoea (difficult or laboured respiration)
  10. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
60+:
  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Arthralgia (joint pain)
  4. Weight decreased
  5. Cough
  6. Chest pain
  7. Pain in extremity
  8. Back pain
  9. Myalgia (muscle pain)
  10. Vomiting

* Approximation only. Some reports may have incomplete information.

Do you take Lipitor and Synthroid?


You are not alone:




Related publications that referenced our studies

Related studies

Browse interactions by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Interactions between Lipitor and drugs from A to Z
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Interactions between Synthroid and drugs from A to Z
a b c d e f g h i j k l m n o p q r s t u v w x y z
Browse all drug interactions of Lipitor and Synthroid
a b c d e f g h i j k l m n o p q r s t u v w x y z

What would happen?

Predict new side effects and undetected conditions when you take Lipitor and Synthroid (97,559 reports studied)



FDA reports used in this study


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