Lisinopril and hydrochlorothiazide and Promethazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lisinopril and hydrochlorothiazide (hydrochlorothiazide; lisinopril) and Promethazine (promethazine hydrochloride). Common drug interactions include decreased appetite among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Lisinopril and hydrochlorothiazide and Promethazine. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Lisinopril and hydrochlorothiazide?

Lisinopril and hydrochlorothiazide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 10,259 Lisinopril and hydrochlorothiazide users. Check the latest studies of Lisinopril and hydrochlorothiazide.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

On Jul, 15, 2026

87 people who take Lisinopril and hydrochlorothiazide and Promethazine together, and have interactions are studied.

Lisinopril and hydrochlorothiazide and Promethazine drug interactions.

What are the common drug interactions of Lisinopril And Hydrochlorothiazide and Promethazine, by gender? *:

female:

Decreased appetite
Electric shock
Fibromyalgia (a long-term condition which causes pain all over the body)
Migraine (headache)
Platelet count decreased
Tremor (trembling or shaking movements in one or more parts of your body)
Visual acuity reduced (reduced clearness of vision)
Blood sodium decreased
Cholecystitis (infection of gallbladder)
Colitis (inflammation of colon)

male:

Chronic kidney disease
Diarrhoea
Disturbance in attention
Dizziness
Emotional distress
Energy increased
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Infusion related reaction
Muscle spasms (muscle contraction)
Muscle twitching

What are the common drug interactions of Lisinopril And Hydrochlorothiazide and Promethazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiac disorder
Chronic kidney disease
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Food aversion (we reject certain foods for a reason)
Gastrointestinal viral infection (virus infection of gastrointestinal tract)
Heart rate increased
Loss of consciousness
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

40-49:

Confusional state
Constipation
Diarrhoea
Disturbance in attention
Dizziness
Energy increased
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Infusion related reaction
Muscle spasms (muscle contraction)

50-59:

Pain
Blood iron decreased
Crying
Nephrogenic anaemia (anaemia due to kidney disease)
Serum serotonin decreased
Vision blurred
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Anxiety
Back pain
Blood creatine phosphokinase increased

60+:

Chronic kidney disease
Fatigue (feeling of tiredness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac failure congestive
Confusional state
Diarrhoea
Dizziness
Drug intolerance (drug sensitivity)
Emotional disorder
Eye disorder

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 19.54%
Pain: 16 people, 18.39%
Stress And Anxiety: 10 people, 11.49%
High Blood Cholesterol: 10 people, 11.49%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 10.34%
Infection: 8 people, 9.20%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 6.90%
Ovarian Cancer (cancer of ovary): 6 people, 6.90%
Migraine (headache): 6 people, 6.90%
Blood Pressure Abnormal: 6 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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