Chlorhexidine gluconate and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorhexidine gluconate (chlorhexidine gluconate) and Zanaflex (tizanidine hydrochloride). Common drug interactions include tooth disorder among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorhexidine gluconate and Zanaflex. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorhexidine gluconate?

Chlorhexidine gluconate has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 8,233 Chlorhexidine gluconate users. Check the latest studies of Chlorhexidine gluconate.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 15, 2026

51 people who take Chlorhexidine gluconate and Zanaflex together, and have interactions are studied.

Chlorhexidine gluconate and Zanaflex drug interactions.

What are the common drug interactions of Chlorhexidine Gluconate and Zanaflex, by gender? *:

female:

Tooth disorder (tooth disease)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Anaemia (lack of blood)
Anxiety
Constipation
Hypertension (high blood pressure)
Oedema peripheral (superficial swelling)
Abdominal pain
Abdominal pain upper

male:

Anxiety
Arthralgia (joint pain)
Hypophagia (reduced food intake)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Arthropathy
Haematochezia (passage of stools containing blood)
Post laminectomy syndrome
Spondylitis (an inflammation of the vertebra with spinal cord involvement)

What are the common drug interactions of Chlorhexidine Gluconate and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

n/a

40-49:

Fatigue (feeling of tiredness)
Abdominal pain
Abdominal pain upper
Actinomycosis (infection that causes sores, or abscesses)
Adverse drug reaction
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)

50-59:

Bacteraemia (presence of bacteria in the blood)
Bone disorder
Bone erosion
Bone fragmentation
Congestive cardiomyopathy (weakening of heart muscle)
Dental fistula
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema asteatotic (severe dry skin- during the winter months and in the elderly)
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)

60+:

Bone loss
Cardiomegaly (increased size of heart than normal)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Osteonecrosis of jaw (death of bone of jaw)
Ovarian cyst (fluid filled sac of the ovary)
Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Quality of life decreased
Road traffic accident
Tooth loss

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 27 people, 52.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 33.33%
High Blood Pressure: 15 people, 29.41%
Fatigue (feeling of tiredness): 14 people, 27.45%
Immunodeficiency Common Variable: 10 people, 19.61%
Pain: 6 people, 11.76%
Metastases To Bone (cancer spreads to bone): 4 people, 7.84%
Stress And Anxiety: 3 people, 5.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.88%
Inflammation: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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