Lisinopril and Mexitil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lisinopril (lisinopril) and Mexitil (mexiletine hydrochloride). Common drug interactions include asthenia among females and mitral valve incompetence among males.

The phase IV clinical study analyzes what interactions people have when they take Lisinopril and Mexitil. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Lisinopril?

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 358,656 Lisinopril users. Check the latest studies of Lisinopril.

What is Mexitil?

Mexitil has active ingredients of mexiletine hydrochloride. eHealthMe is studying from 1,893 Mexitil users. Check the latest studies of Mexitil.

On Aug, 04, 2026

45 people who take Lisinopril and Mexitil together, and have interactions are studied.

Lisinopril and Mexitil drug interactions.

What are the common drug interactions of Lisinopril and Mexitil, by gender? *:

female:

Asthenia (weakness)
Diarrhoea
Hyperkalaemia (damage to or disease of the kidney)
Pyrexia (fever)
Dizziness
Dyspnoea (difficult or laboured respiration)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Headache (pain in head)
Heart rate decreased
Multiple injuries

male:

Mitral valve incompetence (inefficient heart valve)
Cardiomyopathy (weakening of the heart muscle)
Arrhythmia (irregular heartbeat)
Abscess (pus)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Decreased interest
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Osteonecrosis of jaw (death of bone of jaw)

What are the common drug interactions of Lisinopril and Mexitil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Abscess (pus)
Alcoholic liver disease
Anaemia (lack of blood)
Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Anxiety
Arrhythmia (irregular heartbeat)
Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
Arthralgia (joint pain)
Arthropathy

30-39:

n/a

40-49:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiac disorder
Cardiac failure chronic
Cardiac valve disease (heart valve disease)
Cardiomyopathy (weakening of the heart muscle)
Cellulitis (infection under the skin)

50-59:

Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Surgery
Abnormal faeces (abnormal stool)
Dyspnoea (difficult or laboured respiration)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Disease recurrence
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Cardioactive drug level increased
Cardiomegaly (increased size of heart than normal)
Cough

60+:

Renal failure (kidney dysfunction)
Asthenia (weakness)
Multiple injuries
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Vomiting

What are the existing conditions these people have? *

Bone Disorder: 18 people, 40.00%
Multiple Myeloma (cancer of the plasma cells): 10 people, 22.22%
Arrhythmias (irregular heartbeat): 10 people, 22.22%

* Approximation only. Some reports may have incomplete information.

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