Lisinopril and Rayaldee drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lisinopril (lisinopril) and Rayaldee (calcifediol). Common drug interactions include death among females and hip arthroplasty among males.

The phase IV clinical study analyzes what interactions people have when they take Lisinopril and Rayaldee. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Lisinopril?

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 358,656 Lisinopril users. Check the latest studies of Lisinopril.

What is Rayaldee?

Rayaldee has active ingredients of calcifediol. eHealthMe is studying from 342 Rayaldee users. Check the latest studies of Rayaldee.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

20 people who take Lisinopril and Rayaldee together, and have interactions are studied.

Lisinopril and Rayaldee drug interactions.

What are the common drug interactions of Lisinopril and Rayaldee, by gender? *:

female:

Death
Cardiac failure congestive
Chronic kidney disease
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Fluid retention (an abnormal accumulation of fluid in the blood)
Fungal infection
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypercalcaemia (elevated calcium (ca+) level in the blood)

male:

Hip arthroplasty
Death
Dyspepsia (indigestion)
Hallucination (an experience involving the perception of something not present)
Nonspecific reaction (unspecified reaction)
Osteopenia (a condition where bone mineral density is lower than normal)
Dyspnoea (difficult or laboured respiration)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease

What are the common drug interactions of Lisinopril and Rayaldee, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hip arthroplasty
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Pain
Bone density decreased
Renal failure (kidney dysfunction)
Bone loss
Osteopenia (a condition where bone mineral density is lower than normal)

50-59:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vitamin d deficiency

60+:

Death
Dyspepsia (indigestion)
Hypersensitivity
Influenza
Pain
Weight decreased
Hallucination (an experience involving the perception of something not present)
Nonspecific reaction (unspecified reaction)
Cardiac failure congestive
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

What are the existing conditions these people have? *

Hiv Infection: 4 people, 20.00%
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium): 3 people, 15.00%
Renal Cell Carcinoma (a kidney cancer): 2 people, 10.00%
Parkinson's Disease: 2 people, 10.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 10.00%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 2 people, 10.00%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 5.00%
Bone Disorder: 1 person, 5.00%
Calcium Deficiency (lack of calcium): 1 person, 5.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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