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Lisinopril and Vivactil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lisinopril (lisinopril) and Vivactil (protriptyline hydrochloride). Common drug interactions include insomnia among females and dry mouth among males.

The phase IV clinical study analyzes what interactions people have when they take Lisinopril and Vivactil. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Lisinopril?

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 358,654 Lisinopril users. Check the latest studies of Lisinopril.

What is Vivactil?

Vivactil has active ingredients of protriptyline hydrochloride. eHealthMe is studying from 386 Vivactil users. Check the latest studies of Vivactil.

On Jul, 20, 2026

36 people who take Lisinopril and Vivactil together, and have interactions are studied.

Lisinopril and Vivactil drug interactions.

What are the common drug interactions of Lisinopril and Vivactil, by gender? *:

female:

  1. Insomnia (sleeplessness)
  2. Pruritus (severe itching of the skin)
  3. Road traffic accident
  4. Weight increased
  5. Diarrhoea
  6. Dry mouth
  7. Fatigue (feeling of tiredness)
  8. Hysterectomy
  9. Surgery
  10. Ataxia (loss of full control of bodily movements)

male:

  1. Dry mouth
  2. Hospitalisation
  3. Prostate cancer recurrent
  4. Tooth extraction
  5. Ulcer haemorrhage (bleeding ulcer)

What are the common drug interactions of Lisinopril and Vivactil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Abasia (inability to walk)
  2. Arthropathy
  3. Compression fracture (fracture due to pressure caused by injury)
  4. Deafness
  5. Drug ineffective
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Oral disorder (mouth disease)
  8. Retinal disorder (disease of retina)
  9. Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
  10. Cheilitis (infection of lips)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Dry mouth
  2. Tooth extraction

60+:

  1. Diarrhoea
  2. Anaemia (lack of blood)
  3. Dyspareunia (painful sexual intercourse)
  4. Essential hypertension (primary hypertension)
  5. Fatigue (feeling of tiredness)
  6. Hypersensitivity
  7. Hypersomnia (excessive daytime sleepiness (eds))
  8. Hysterectomy
  9. Joint injury
  10. Lacrimation increased

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 28 people, 77.78%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 27 people, 75.00%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.33%
  4. Sleep Disorder: 2 people, 5.56%
  5. Depression: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Lisinopril and Vivactil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lisinopril and Vivactil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lisinopril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vivactil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lisinopril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vivactil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lisinopril and protriptyline hydrochloride (the active ingredients of Lisinopril and Vivactil, respectively), and Lisinopril and Vivactil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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