Lodine and Senna drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lodine (etodolac) and Senna (senna). Common drug interactions include depression among females and femoral neck fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Lodine and Senna. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Lodine?

Lodine has active ingredients of etodolac. It is often used in pain. eHealthMe is studying from 3,846 Lodine users. Check the latest studies of Lodine.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

20 people who take Lodine and Senna together, and have interactions are studied.

What are the common drug interactions of Lodine and Senna, by gender? *:

female:

Depression
High density lipoprotein decreased
Menopausal symptoms
Pyrexia (fever)
Muscle spasms (muscle contraction)
Asthenia (weakness)
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

male:

Femoral neck fracture (neck of femur bone fracture)
Haematocrit decreased
Hypotension (abnormally low blood pressure)
Arthralgia (joint pain)
Benign neoplasm (benign (non-cancerous) tumour)
Pain in jaw
Peripheral swelling
Prostatic specific antigen increased

What are the common drug interactions of Lodine and Senna, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Faeces discoloured
Hypokalaemia (low potassium)

30-39:

n/a

40-49:

Thyroid neoplasm (tumour of thyroid)
Upper respiratory tract infection
Urinary retention (the inability to completely or partially empty the bladder)
Vaginal infection
Vomiting
White blood cell count increased
Hypokalaemia (low potassium)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Bone pain
Exposed bone in jaw

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Depression
Fall
Insomnia (sleeplessness)
Joint effusion (presence of extra fluid in joint covering)
Muscle spasms (muscle contraction)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)
Panic reaction
Psychogenic pain disorder

60+:

Femoral neck fracture (neck of femur bone fracture)
Haematocrit decreased
Hypotension (abnormally low blood pressure)

What are the existing conditions these people have? *

Stress And Anxiety: 10 people, 50.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 15.00%
Breast Cancer: 3 people, 15.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 10.00%
Cough: 2 people, 10.00%
Inflammation: 1 person, 5.00%
Asthma: 1 person, 5.00%
Athlete's Foot (a fungal infection affecting the skin between the toes): 1 person, 5.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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