Lomotil and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include mental disorder among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Lomotil and Fiorinal. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

46 people who take Lomotil and Fiorinal together, and have interactions are studied.

What are the common drug interactions of Lomotil and Fiorinal, by gender? *:

female:

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Foot fracture
Pain in extremity
Osteoporosis (bones weak and more likely to break)
Pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)

male:

Anaemia (lack of blood)
Cellulitis (infection under the skin)
Oedema peripheral (superficial swelling)
Pain
Suicide attempt
Epistaxis (bleed from the nose)
Gamma-glutamyltransferase increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Anxiety
Cardiac disorder

What are the common drug interactions of Lomotil and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Enteritis (inflammation of the small intestine)
Hypokalaemia (low potassium)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Uterine cyst
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Vomiting
Anaemia (lack of blood)
Chest pain

40-49:

Anaemia (lack of blood)
Cellulitis (infection under the skin)
Epistaxis (bleed from the nose)
Gamma-glutamyltransferase increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pain
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Apnoea (suspension of external breathing)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

50-59:

Anxiety
Depression
Small intestinal obstruction (blockage in small intestine)
Abdominal pain
Abnormal behaviour
Aggression
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dizziness
Emotional distress
Impaired driving ability

60+:

Anxiety
Arthropathy
Pneumonia
Weakness
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Cartilage atrophy (cartilage extra growth)
Dehydration (dryness resulting from the removal of water)
Hypertension (high blood pressure)
Injection site bruising

What are the existing conditions these people have? *

Pain: 16 people, 34.78%
Headache (pain in head): 10 people, 21.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 15.22%
Urinary Tract Infection: 6 people, 13.04%
Diabetes: 6 people, 13.04%
Nausea (feeling of having an urge to vomit): 6 people, 13.04%
Insomnia (sleeplessness): 6 people, 13.04%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 10.87%
Immunodeficiency Common Variable: 5 people, 10.87%
Gout (uric acid crystals building up in the body): 5 people, 10.87%

* Approximation only. Some reports may have incomplete information.

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