Loniten and Clonidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loniten (minoxidil) and Clonidine (clonidine). Common drug interactions include cardiac murmur among females and conjunctival haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Loniten and Clonidine. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Loniten?

Loniten has active ingredients of minoxidil. eHealthMe is studying from 363 Loniten users. Check the latest studies of Loniten.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.



On Jul, 10, 2026

37 people who take Loniten and Clonidine together, and have interactions are studied.

Loniten and Clonidine drug interactions.

What are the common drug interactions of Loniten and Clonidine, by gender? *:

female:

  1. Cardiac murmur (an heart sound in valve abnormality)
  2. Cardiomyopathy (weakening of the heart muscle)
  3. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  4. Cough
  5. Diplopia (double vision)
  6. Fatigue (feeling of tiredness)
  7. Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
  8. Fluid overload (too much fluid in the blood)
  9. Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
  10. Hypermagnesaemia (an electrolyte disturbance in which there is an abnormally elevated level of magnesium in the blood)

male:

  1. Conjunctival haemorrhage (bleeding underneath the conjunctiva)
  2. Headache (pain in head)
  3. Loss of consciousness
  4. Poor venous access
  5. Renal failure (kidney dysfunction)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Back pain
  8. Balance disorder
  9. Chronic kidney disease
  10. Dysarthria (speech disorder)

What are the common drug interactions of Loniten and Clonidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

  1. Blood glucose increased
  2. Cardiomegaly (increased size of heart than normal)
  3. Dizziness
  4. Dyspnoea (difficult or laboured respiration)
  5. Electrocardiogram qt prolonged
  6. Haemoglobin decreased
  7. Hypersensitivity
  8. Lethargy (tiredness)
  9. Muscular weakness (muscle weakness)
  10. Nausea (feeling of having an urge to vomit)

50-59:

  1. Eyelid oedema (eyelids are swollen and contain excessive fluid)
  2. Loss of consciousness
  3. Poor venous access
  4. Balance disorder
  5. Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
  6. Dizziness
  7. Head discomfort
  8. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
  9. Back pain
  10. Dry mouth

60+:

  1. Anaphylactic reaction (serious allergic reaction)
  2. Chronic kidney disease
  3. Renal injury (kidney injury)
  4. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  5. Vertigo
  6. Abdominal hernia
  7. Abdominal tenderness
  8. Abnormal sleep-related event
  9. Anastomotic complication (complication of surgical connection between two structures)
  10. Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)

What are the existing conditions these people have? *

  1. Chest Pain: 6 people, 16.22%
  2. Nuclear Magnetic Resonance Imaging Brain: 5 people, 13.51%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 13.51%
  4. Pain: 3 people, 8.11%
  5. Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 8.11%
  6. Weight Decreased: 2 people, 5.41%
  7. Type 2 Diabetes: 2 people, 5.41%
  8. Hypotension (abnormally low blood pressure): 2 people, 5.41%
  9. High Blood Cholesterol: 2 people, 5.41%
  10. Diabetes: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Loniten and Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Loniten:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Loniten and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Clonidine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on minoxidil and clonidine (the active ingredients of Loniten and Clonidine, respectively), and Loniten and Clonidine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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